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Gene transfer to the corneal endothelium has potential for modulating rejection of corneal grafts. It can also serve as a convenient and useful model for gene therapy of other organs. In this article we review the work carried out in our laboratory using both viral and nonviral vectors to obtain gene expression in the cornea.

Original publication

DOI

10.1164/ajrccm.162.supplement_3.15tac11

Type

Journal article

Journal

American journal of respiratory and critical care medicine

Publication Date

10/2000

Volume

162

Pages

S194 - S200

Addresses

Department of Immunology, Division of Medicine, Imperial College, Hammersmith Hospital, London; and Moorfields Eye Hospital, London, United Kingdom.

Keywords

Endothelium, Corneal, Animals, Humans, Adenoviridae, Gene Transfer Techniques, Transplantation Tolerance, Graft Rejection, Genetic Vectors