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Gene transfer to the corneal endothelium has potential for modulating rejection of corneal grafts. It can also serve as a convenient and useful model for gene therapy of other organs. In this article we review the work carried out in our laboratory using both viral and nonviral vectors to obtain gene expression in the cornea.


Journal article


American journal of respiratory and critical care medicine

Publication Date





S194 - S200


Department of Immunology, Division of Medicine, Imperial College, Hammersmith Hospital, London; and Moorfields Eye Hospital, London, United Kingdom.


Endothelium, Corneal, Animals, Humans, Adenoviridae, Gene Transfer Techniques, Transplantation Tolerance, Graft Rejection, Genetic Vectors