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CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control of lymphocytic choriomeningitis virus (LCMV), a prototypic mouse model of systemic persistent infection. Mice expressing transgenic B cell receptors of LCMV-unrelated specificity, and mice unable to produce soluble immunoglobulin M (IgM) exhibited protracted viremia or failed to resolve LCMV. Virus control depended on immunoglobulin class switch, but neither on complement cascades nor on Fc receptor gamma chain or Fc gamma receptor IIB. Cessation of viremia concurred with the emergence of viral envelope-specific antibodies, rather than with neutralizing serum activity, and even early nonneutralizing IgM impeded viral persistence. This important role for virus-specific antibodies may be similarly underappreciated in other primarily T cell-controlled infections such as HIV and hepatitis C virus, and we suggest this contribution of antibodies be given consideration in future strategies for vaccination and immunotherapy.

Original publication

DOI

10.1371/journal.pbio.1000080

Type

Journal article

Journal

PLoS biology

Publication Date

04/2009

Volume

7

Addresses

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. andreas.bergthaler@gmail.com

Keywords

CD8-Positive T-Lymphocytes, Animals, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Lymphocytic choriomeningitis virus, Viremia, Virus Diseases, Arenaviridae Infections, Disease Models, Animal, Immunoglobulin G, Immunoglobulin M, Receptors, Antigen, B-Cell, Antibodies, Viral, Viral Load, Immunoglobulin Class Switching, Complement System Proteins