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Paired data occur in crossover trials and matched case-control studies, and it is rare to find studies reporting sample size calculations associated with these types of studies, despite recommendations from editors that sample size calculations should be justified. In this article we describe some simple formulas and strategies for calculating the number of patients that should be entered into a matched or paired study when the outcome measures are continuous, binary, or ordinal.

Original publication

DOI

10.1081/bip-100101174

Type

Journal article

Journal

Journal of biopharmaceutical statistics

Publication Date

05/1999

Volume

9

Pages

241 - 251

Addresses

Clinical Pharmacology Data Sciences, Glaxo Wellcome, Greenford, London, UK.

Keywords

Humans, Cholesterol, Anticholesteremic Agents, Case-Control Studies, Cross-Over Studies, Sample Size, Family Practice, Aged, Child, Child, Preschool, Office Visits, Female, Male, Clinical Trials as Topic, Statistics as Topic