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Paired data occur in crossover trials and matched case-control studies, and it is rare to find studies reporting sample size calculations associated with these types of studies, despite recommendations from editors that sample size calculations should be justified. In this article we describe some simple formulas and strategies for calculating the number of patients that should be entered into a matched or paired study when the outcome measures are continuous, binary, or ordinal.

Original publication

DOI

10.1081/BIP-100101174

Type

Journal article

Journal

J Biopharm Stat

Publication Date

05/1999

Volume

9

Pages

241 - 251

Keywords

Aged, Anticholesteremic Agents, Case-Control Studies, Child, Child, Preschool, Cholesterol, Clinical Trials as Topic, Cross-Over Studies, Family Practice, Female, Humans, Male, Office Visits, Sample Size, Statistics as Topic