Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

To determine whether atrial fibrillation is a stronger risk factor for cardiovascular disease and death in women compared with men.Meta-analysis of cohort studies.Studies published between January 1966 and March 2015, identified through a systematic search of Medline and Embase and review of references.Cohort studies with a minimum of 50 participants with and 50 without atrial fibrillation that reported sex specific associations between atrial fibrillation and all cause mortality, cardiovascular mortality, stroke, cardiac events (cardiac death and non-fatal myocardial infarction), and heart failure.Two independent reviewers extracted study characteristics and maximally adjusted sex specific relative risks. Inverse variance weighted random effects meta-analysis was used to pool sex specific relative risks and their ratio.30 studies with 4,371,714 participants were identified. Atrial fibrillation was associated with a higher risk of all cause mortality in women (ratio of relative risks for women compared with men 1.12, 95% confidence interval 1.07 to 1.17) and a significantly stronger risk of stroke (1.99, 1.46 to 2.71), cardiovascular mortality (1.93, 1.44 to 2.60), cardiac events (1.55, 1.15 to 2.08), and heart failure (1.16, 1.07 to 1.27). Results were broadly consistent in sensitivity analyses.Atrial fibrillation is a stronger risk factor for cardiovascular disease and death in women compared with men, though further research would be needed to determine any causality.

Original publication

DOI

10.1136/bmj.h7013

Type

Journal article

Journal

BMJ : British Medical Journal

Publication Date

19/01/2016

Volume

532

Addresses

George Institute for Global Health, University of Oxford, Oxford, UK cemdin@georgeinstitute.org.uk.

Keywords

Humans, Cardiovascular Diseases, Atrial Fibrillation, Death, Sudden, Cardiac, Myocardial Infarction, Risk Factors, Sex Factors, Female, Male, Heart Failure, Stroke