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Hematopoietic stem/progenitor cells (HSPCs) reside in specialized bone marrow microenvironmental niches, with vascular elements (endothelial/mesenchymal stromal cells) and CXCR4-CXCL12 interactions playing particularly important roles for HSPC entry, retention, and maintenance. The functional effects of CXCL12 are dependent on its local concentration and rely on complex HSPC-niche interactions. Two Junctional Adhesion Molecule family proteins, Junctional Adhesion Molecule-B (JAM)-B and JAM-C, are reported to mediate HSPC-stromal cell interactions, which in turn regulate CXCL12 production by mesenchymal stromal cells (MSCs). Here, we demonstrate that another JAM family member, JAM-A, is most highly expressed on human hematopoietic stem cells with in vivo repopulating activity (p 

Original publication

DOI

10.1002/stem.2340

Type

Journal article

Journal

Stem cells

Publication Date

06/2016

Volume

34

Pages

1664 - 1678

Keywords

CXCL12, CXCR4, Hematopoietic stem/progenitor cells, JAM-A, NSG transplants, Vascular niche, AC133 Antigen, Antigens, CD34, Bone Marrow Cells, Cell Adhesion, Chemokine CXCL12, Endothelial Cells, Fetal Blood, Gene Knockdown Techniques, HL-60 Cells, Hematopoietic Stem Cells, Humans, Junctional Adhesion Molecule A, Jurkat Cells, Protein Binding, Receptors, CXCR4, Stem Cell Niche