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Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.

Original publication

DOI

10.1038/ncb2924

Type

Journal article

Journal

Nature cell biology

Publication Date

03/2014

Volume

16

Pages

212 - 214

Addresses

Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Comprehensive Cancer Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California, USA.

Keywords

Animals, Humans, Adenocarcinoma, Colorectal Neoplasms, Transcription Factors, MicroRNAs, Mitosis, Female, Neoplastic Stem Cells, Snail Family Transcription Factors