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Cytokines are soluble mediators of cell communication that are critical in immune regulation. They induce specific gene-expression programs in responsive cells. Recent findings, however, indicate that cytokine receptors can regulate immune cell functions by transcription-independent mechanisms. Here we review the current understanding of how cytokine signaling regulates the functions of other signaling pathways by first discussing the 'traditional' transcription-mediated consequences of cytokine signaling and then providing a detailed description of transcription-independent lateral communications between cytokine receptors and other cellular receptors.

Original publication




Journal article


Nat immunol

Publication Date





333 - 339


Animals, Cell Communication, Cytokines, Humans, Janus Kinases, Models, Biological, Receptor Cross-Talk, Receptors, Cytokine, STAT Transcription Factors, Signal Transduction, Transcription, Genetic