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Recent results have increased our understanding of normal stem cells and the signalling pathways which regulate them during the development of the mammary gland. Tumours in many tissues are now thought to develop from dysregulated stem cells and depend on activated stem cell self-renewal pathways such as Notch for their tumourigenic capacity. These cancer stem cells are recognised by specific cell surface proteins that they express and their capacity to grow tumours in vivo or spheres in vitro. We have described human breast DCIS mammospheres grown from cancer stem cells and demonstrated their dependence on the EGF and Notch receptor pathways. Stem cell self-renewal pathways such as these may represent novel therapeutic targets to prevent recurrence of pre-invasive and invasive breast cancer.

Type

Journal article

Journal

Ernst Schering Foundation symposium proceedings

Publication Date

01/2006

Pages

141 - 153

Addresses

Breast Biology Group, School of Cancer and Imaging Sciences, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, M20 4BX Manchester, UK.

Keywords

Breast, Stem Cells, Humans, Breast Neoplasms, Epidermal Growth Factor, Signal Transduction, Receptors, Notch