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There has been a tremendous amount of research in the past decade to optimize the mechanical properties and degradation behavior of the biodegradable Mg alloy for orthopedic implant. Despite the feasibility of degrading implant, the lack of fundamental understanding about biocompatibility and underlying bone formation mechanism is currently limiting the use in clinical applications. Herein, we report the result of long-term clinical study and systematic investigation of bone formation mechanism of the biodegradable Mg-5wt%Ca-1wt%Zn alloy implant through simultaneous observation of changes in element composition and crystallinity within degrading interface at hierarchical levels. Controlled degradation of Mg-5wt%Ca-1wt%Zn alloy results in the formation of biomimicking calcification matrix at the degrading interface to initiate the bone formation process. This process facilitates early bone healing and allows the complete replacement of biodegradable Mg implant by the new bone within 1 y of implantation, as demonstrated in 53 cases of successful long-term clinical study.

Original publication

DOI

10.1073/pnas.1518238113

Type

Journal article

Journal

Proceedings of the national academy of sciences of the united states of america

Publication Date

04/01/2016

Volume

113

Pages

716 - 721

Addresses

School of Advanced Materials Engineering, Kookmin University, Seoul 136-702, South Korea;

Keywords

Femur, Animals, Rabbits, Humans, Magnesium, Alloys, Prosthesis Implantation, Follow-Up Studies, Absorbable Implants, Wound Healing, Osteogenesis, Time Factors, Female, Male