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In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.

Original publication

DOI

10.1146/annurev-cellbio-111315-124936

Type

Book

Publication Date

10/2016

Volume

32

Pages

649 - 675

Addresses

Faculty of Medicine, University of Münster, D-48149 Münster, Germany.

Keywords

Blood Vessels, Endothelial Cells, Bone Marrow, Animals, Humans, Signal Transduction, Hematopoiesis, Osteogenesis