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Leukocyte recruitment to tissues is a highly orchestrated process and is one of the pillars of the inflammatory process. The contribution of leukocytes to tissue damage is very clear, suggesting that targeting leukocyte accumulation in tissue to be relevant for the development of novel therapies to treat chronic inflammatory diseases. Here, we review briefly known mechanisms of leukocyte recruitment and suggest potential targets for the development of novel anti-inflammatory therapies.

Original publication

DOI

10.1016/j.phrs.2016.01.015

Type

Journal article

Journal

Pharmacological research

Publication Date

10/2016

Volume

112

Pages

37 - 48

Addresses

Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.

Keywords

Leukocytes, Humans, Chronic Disease, Inflammation, Selectins, Receptors, Chemokine, Anti-Inflammatory Agents, Signal Transduction, Chemotaxis, Leukocyte, Leukocyte Rolling, Drug Discovery, Molecular Targeted Therapy