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The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms. Here, we give a brief overview of the human Trx and Grx systems. The main part focuses on our current knowledge about mitochondrial Grx2, which facilitates mitochondrial redox homoeostasis during oxidative stress-induced apoptosis.

Original publication

DOI

10.1042/bst20051375

Type

Journal article

Journal

Biochemical Society transactions

Publication Date

12/2005

Volume

33

Pages

1375 - 1377

Addresses

Department of Medical Biochemistry and Biophysics, The Medical Nobel Institute for Biochemistry, Karolinska Institutet, SE-17177 Stockholm, Sweden. Arne.Holmgren@mbb.ki.se

Keywords

Mitochondria, Animals, Humans, Reactive Oxygen Species, Sulfhydryl Compounds, Oxidoreductases, Signal Transduction, Oxidation-Reduction, Oxidative Stress, Thioredoxins, Glutaredoxins