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The bulk of strong nucleosomes (SNs, with visibly periodic DNA sequences) is described by consensus pattern of 5 or 6 base runs of purines alternating with similar runs of pyrimidines - RR/YY SNs. Yet, the strongest known nucleosome positioning sequence, the 601 clone of Lowary and Widom, is rather periodic repetition of TA dinucleotides following one another every 10 bases. We located "601"-like TA-periodic sequences in the genome of A. thaliana. Several families of such sequences are discovered repeating almost exclusively in centromeres. Thus, while A. thaliana SNs of RR/YY type have strong affinity to pericentromeric regions, as it has been previously found, the SNs of TA periodic type concentrate rather in centromeres.

Original publication




Journal article


Journal of biomolecular structure & dynamics

Publication Date





448 - 451


a Genome Diversity Center, Institute of Evolution , University of Haifa , Haifa , Israel.


Chromosomes, Plant, Centromere, Nucleosomes, Arabidopsis, DNA, Satellite, Base Sequence, Repetitive Sequences, Nucleic Acid, Base Pairing, Molecular Sequence Data