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Don Crothers, Mikael Kubista, Jon Widom, and their teams have been first to look for strong nucleosomes, in a bid to reveal the nucleosome positioning pattern(s) carried by the nucleosome DNA sequences. They were first to demonstrate that the nucleosome stability correlates with 10-11 base sequence periodicity, and that the strong nucleosomes localize preferentially in centromeres. This review describes these findings and their connection to recent discovery of the strong nucleosomes (SNs) with visibly periodic nucleosome DNA sequences.

Original publication

DOI

10.1002/bip.22604

Type

Journal article

Journal

Biopolymers

Publication Date

08/2015

Volume

103

Pages

432 - 437

Addresses

Institute of Evolution, University of Haifa, Haifa, Israel.

Keywords

Centromere, Chromatin, Nucleosomes, Humans, Sequence Analysis, DNA