Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We review and discuss the practical problems encountered when analysing the effect on survival of covariates which are measured repeatedly over time. Specific issues arise over and above those met with the standard proportional hazards model and concern all stages of data preparation, data analysis and interpretation of the results. Data from a randomized clinical trial of patients with primary biliary cirrhosis, on whom several measurements were taken at regular intervals after entry, are presented as an illustration.

Type

Journal article

Journal

Stat med

Publication Date

28/02/1994

Volume

13

Pages

301 - 341

Keywords

Aged, Analysis of Variance, Azathioprine, Clinical Trials as Topic, Double-Blind Method, Female, Follow-Up Studies, Humans, Liver Cirrhosis, Biliary, Male, Mathematical Computing, Middle Aged, Proportional Hazards Models, Software, Survival Analysis