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Despite the fundamental importance of measurement in medicine, studies which compare methods of clinical measurement are often analysed inappropriately and may thus come to incorrect conclusions. We explain the problems with the main methods used, notably correlation and regression, and describe the limits of agreement approach which we have proposed. We consider why incorrect methods are so widely used and describe our own experience in bringing this issue to the attention of medical researchers.

Original publication




Journal article


Int j epidemiol

Publication Date



24 Suppl 1


S7 - 14


Clinical Medicine, Data Interpretation, Statistical, Epidemiologic Methods, Humans, Peak Expiratory Flow Rate, Reproducibility of Results, Respiratory Function Tests