O-substituted alkyl aldehydes for rhodium-catalyzed intermolecular alkyne hydroacylation: the utility of methylthiomethyl ethers.

Parsons SR., Hooper JF., Willis MC.

Combining α-methylthiomethyl (MTM) ether substituted aldehydes and 1-alkynes in the presence of [Rh(dppe)]ClO(4) results in efficient intermolecular alkyne hydroacylation to deliver α-O-MTM-substituted enone products. The product MTM ethers can be converted to the free hydroxyl group either in situ, by the addition of water to the completed reaction, or in a separate operation, by the action of silver nitrate.

DOI

10.1021/ol1030662

Type

Journal article

Publication Date

2011-03-04T00:00:00+00:00

Volume

13

Pages

998 - 1000

Total pages

2

Keywords

Aldehydes, Alkynes, Catalysis, Combinatorial Chemistry Techniques, Ethers, Ketones, Molecular Structure, Rhodium, Silver Nitrate, Water

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