The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly evident that LFA-1 has additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or APCs. These include roles in homotypic T cell-T cell (T-T) communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we briefly summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.
Journal article
2021-08-01T00:00:00+00:00
42
706 - 722
16
LFA-1, PTPN22, WNK1, adhesion, complement, mechanosensing, mechanotransduction, Animals, Antigen-Presenting Cells, Cell Differentiation, Intercellular Adhesion Molecule-1, Lymphocyte Function-Associated Antigen-1, Th1 Cells