Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Athero-B-Cell Project aims to overcome the limitations of existing therapeutics by targeting only defined B cell subsets with specific pathogenic or regulatory functions.  An experimental platform that permits the identification and selective targeting of mature B cell type(s) that either promote or prevent atherosclerosis and autoimmunity is lacking.

Athero-B-Cell Project intends to identify differences in B cell effector subsets relevant to atherosclerosis and investigate how these differences can be used to develop new cardiovascular disease (CVD) therapeutics.

Refining therapeutic strategy to address defined subsets of B cells has the potential to avoid risks of immunosuppression.  This will be achieved by combining the multidisciplinary knowledge and expertise of Athero-B-Cell Project Consortium members on B cells in inflammation and atherosclerosis with the data mining and therapeutic targeting platforms of world leading SMEs.

Project objectives

Objective 1: To define targets to reduce activation of pathogenic B cells and antibodies in Cardiovascular Diseases.

Objective 2: To identify enhancers of atheroprotective B regulatory cell populations and antibodies in Cardiovascular Diseases.

Objective 3: To validate molecular and miRNA targets to modulate B cell behavior in Cardiovascular Diseases with innovative locked nucleic acid (LNA) based antisense platforms.

Project details

Acronym: Athero-B-Cell
EC Contribution: € 5.892.178
Duration: 60 months
Starting date: 01/09/2013
Instrument: Collaborative project - small or
medium-scale focused research project

Project coordinator:
The Chancellor, Master and Scholars of University of Oxford Prof. Claudia Monaco
Kennedy Institute of Rheumatology
Roosevelt Drive, Headington, Oxford, OX3 7FY, UK.