Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Genetic and environmental factors that control inflammation-driven colon cancer

Project Aims

Intestinal homeostasis is achieved through tightly regulated crosstalk between local immune cells, intestinal epithelial cells and beneficial microbes that reside in our gut. These interactions influence bacterial colonisation, immune cell function, and promote the integrity of the intestinal epithelial cell layer. Disruption of this mutualism – usually resulting from a combination of genetic and environmental factors – leads to chronic intestinal inflammation, a risk factor for development of colorectal cancer.

This project will examine how microbial and cytokine signals influence epithelial and stem cell function in the gut to promote the transition from inflammation to cancer. These studies offer to reveal new therapeutic targets for inflammatory bowel disease and colorectal cancer.

 ERC logo

ERC Advanced Grants allow exceptional established research leaders of any nationality and any age to pursue ground-breaking, high-risk projects that open new directions in their respective research fields or other domains.

Our project

€2.48M ERC Advanced Grant

Started March 2014

Duration: 5 years