Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Hulley group research is directed towards understanding skeletal tissue disease pathology and devising effective regenerative strategies.

Human mini-bone
Osteocytes and osteoblasts in self-assembling organotypic mini-bone

The group combines human tissue omics with organotypic culture approaches. 3D multi-lineage organotypic bones and tendons are generated from patient-derived human primary cells or iPSC with CRISPR mutations. These are used for drug discovery and rare bone disease modelling. Multiphasic tissues are currently in development. Ongoing comparison is made to data derived from single cell atlases of bone and  tendon, as well as large scale synovial fluid proteomics studies.

Recent publications

Related research themes