Oxidative stress in endometriosis induces IL-8 release directly via 4-HNE

Elger BJ., Mueller J., Morton KJ., Kessler B., Becker CM., Steers G., Thezenas M-LR., Zondervan KT., Zollner TM., Oppermann U.

Lipid peroxidation products, e.g. 4-hydroxynonenal (4-HNE), are generated by oxidative stress, and are suggested to cause endometriosis-associated pain following iron overload after retrograde menstrual bleeding. Our aim was to determine the role of oxidative stress including 4-HNE protein adduct formation in endometriotic lesions and in peritoneal fluid from endometriosis patients; and characterise the proinflammatory effects caused by 4-HNE in endometriosis.

DOI

10.1177/1933719118759999

Type

Conference paper

Publisher

SAGE Publications

Publication Date

2018-02-28T00:00:00+00:00

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