Weight-bearing in Ankle Fractures
\n \n\n \n \nThe Dakin Group undertakes translational research focusing on identifying the cellular and molecular basis of inflammatory fibrotic soft tissue joint diseases, with research programmes on tendinopathy, frozen shoulder and knee arthrofibrosis. Understanding the cellular and molecular basis of these diseases will inform new therapeutic approaches targeting tissue resident stromal cells of the joint, to promote resolution of inflammatory fibrotic disease.
\n \n\n \n \nSegmental Tibial fractures, reamed Intramedullary nailing versus circular Frame external Fixation A feasibility study
\n \n\n \n \nA multi centre randomised controlled trial comparing intra operative cell salvage with standard care in the treatment of hip fractures
\n \n\n \n \nThe Fractured Ankle Management Evaluation
\n \n\n \n \nThe Spinal Fusion Indications and Outcomes Randomised Trial (SpInOuT)
\n \n\n \n \nART (Arterial Revascularisation Trial) is led by Professor David Taggart, Professor of Cardiovascular Surgery, University of Oxford.
\n \n\n \n \nHand Osteoarthritis: investigating Pain Effects in a randomised placebo-controlled feasibility study of estrogen-containing therapy (HOPE-e)
\n \n\n \n \nThe UK TAVI Trial is a multi-centre randomised controlled trial to assess the clinical effectiveness and cost-utility of TAVI, compared with conventional surgical aortic valve replacement.
\n \n\n \n \nSurgery or Cast for Injuries of the EpicoNdyle in Children\u2019s Elbows: A multi-centre prospective randomised superiority trial of operative fixation versus non-operative treatment for medial epicondyle fractures of the humerus.
\n \n\n \n \nThis is a multi-centre randomised phase 2 trials in patients with known BRCA Defective Tumours
\n \n\n \n \nThis is a single centre Phase 1 trial of the PI3K inhibitor BKM120, given concomitantly with palliative radiotherapy for the treatment of Non-Small Cell Lung Cancer (NSCLC).
\n \n\n \n \nThis is a multi-centre randomised trial of chemotherapy with chemotherapy plus radioembolisation for colorectal cancer that has spread to the liver
\n \n\n \n \nThis is a multi-centre randomised, double blind, placebo-controlled, parallel group trial of the effectiveness of the nocturnal use of a Temperature Controlled Laminar Airflow (TLA) Device (Airsonett\u00ae) in adults with poorly-controlled, severe allergic asthma
\n \n\n \n \nThis is a single-centre prospective phase 0 tranlational study for predicting response of high grade serious ovarian cancers to paclitaxel chemotherapy
\n \n\n \n \nThis is a multi-centre randomised controlled trial of a treatment patient aimed to reduce the frequency of falls in those with Parkinson's disease.
\n \n\n \n \nThis is a validation study on a prognostic tool for ankle sprains
\n \n\n \n \nThis is a phase 1 non-randomised trial to investigate the feasibility of targeted release of Doxorubicin from Lyso-thermosensitive Liposomal (LTSL) Doxorubicin (ThermoDox (R) using focused ultrasound in patients with liver metastases from lung, breast or colorectal primary tumours.
\n \n\n \n \nThis is a multi-centre European Phase 1 study of MEK1/2 inhibitor PD-0325901 with c-MET inhibitor PF-02341066 in KRASMT and KRASWT (with aberrant c-MET) Colorectal Cancer Patients.
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