Patients with chronic kidney impairment suffer from bone fragility. Yet, most fracture protective therapies are contraindicated for them due to uncertainty on specific safety issues. We will use anonymised electronic medical records data from patients who have used first line anti-osteoporosis treatments (i.e. The so called bisphosphonates) to explore their potential benefits (fracture risk reduction) and risks.
\n \n\n \n \nA pragmatic multi-centre, blinded, randomised placebo-controlled trial comparing Platelet Rich Plasma injection (PRP) to placebo (imitation) injection in adults with Achilles tendon rupture. Two sub-studies are embedded within the main study to contribute to the understanding of the PRP mechanism in tendon healing.
\n \n\n \n \nUK Study of Tendo Achilles Rehabilitation
\n \n\n \n \nWorld Hip Trauma Evaluation Four
\n \n\n \n \nThe NINJA study is a pilot study which will assess whether a study that looks at whether nail plates should be discarded or replaced after nail bed injury in children is feasible in the NHS.
\n \n\n \n \nThe Physiotherapy Rehabilitation for Osteoporotic Vertebral Fracture (PROVE) study is a clinical trial planning to compare usual care versus an exercise based intervention versus a manual therapy based intervention. It aims to recruit 600 patients from centres across the UK.
\n \n\n \n \nTo determine whether oral antibiotics are non-inferior to intravenous antibiotics for serious bone and joint infection judged by the percentage of patients experiencing definitive treatment failure during 1 year of follow up.
\n \n\n \n \nNDORMS coordinated this multicentre randomised controlled trial (RCT) at 32 hospitals in the UK with 51 surgeons via the Surgical Intervention Trials Unit (SITU) and in collaboration with co-chief investigators Professors David Beard and Andrew Carr. The trial was funded by Arthritis Research UK (Ref.19707)
\n \n\n \n \nThe CORKA study was developed in response to a commissioned call by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme for research into a functional home based rehabilitation programme for patients who may be at risk of poor outcome after knee arthroplasty.
\n \n\n \n \nA pragmatic UK multi-centre randomised controlled trial comparing Close Contact Casting technique (CCC) to Open Surgical Reduction and Internal Fixation (ORIF) in the treatment of unstable ankle fractures in patients over 60 years of age.
\n \n\n \n \nPlastic surgery is a small surgical specialty covering hand surgery, trauma, congenital defects, burns and cancer. Plastic surgeons work with all other surgical specialties to undertake complex reconstructions and save lives.
\n \n\n \n \nThe ACHE (Arthroplasty Candidacy Help Engine) Tool
\n \n\n \n \nThe EQUATOR Network is an international initiative set up to help researchers and journals to publish well-reported, reliable, and usable research papers. The UK EQUATOR Centre, based in NDORMS, is the head office and flagship centre of the EQUATOR Network.
\n \n\n \n \nOur research focuses on the clinical and cost effectiveness of orthopaedic surgery.
\n \n\n \n \nProfessor Rees has research themes aimed at improving the treatments and care of orthopaedic patients by IMPROVING TREATMENT DELIVERY TO PATIENTS THROUGH TECHNOLOGY INNOVATIONS, TRIALS AND EPIDEMIOLOGY.
\n \n\n \n \nHulley group research is directed towards understanding skeletal tissue disease pathology and devising effective regenerative strategies.
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