19 May 2025
\n \n \n \nA new study supports the strategy of using early MRI scans to significantly improve care and experiences for patients with wrist injuries.
\n \n\n \n \n15 May 2025
\n \n \n \nA team at NDORMS, University of Oxford has successfully administered a pioneering treatment to a patient with XIAP deficiency, a rare genetic disorder.
\n \n\n \n \n1 May 2025
\n \n \n \nResearchers have developed an innovative dual-receptor T-cell therapy that promises safer and more effective cancer treatments. This study, published in Cell, demonstrates that engineering T-cells to express both a Chimeric Antigen Receptor (CAR) and a T-cell Receptor (TCR) can improve their ability to distinguish between cancerous and healthy tissues\u2014addressing a major challenge in current immunotherapy.
\n \n\n \n \n25 April 2025
\n \n \n \nA new study led by the University of Oxford has revealed that a common and usually harmless virus may positively influence how skin cancer patients respond to current treatments.
\n \n\n \n \n23 April 2025
\n \n \n \nDr Karthik Ramasamy and team will assess a new mass spectrometry-based monitoring technique for its ability to predict and identify early disease relapse.
\n \n\n \n \n22 April 2025
\n \n \n \nResearchers at the University of Oxford have developed a new drug delivery system using ultrasound-activated nanoparticles to break through and destroy bacterial biofilms. This offers a promising solution that could address the global crisis of chronic antibiotic-resistant infections affecting hundreds of millions of people worldwide.
\n \n\n \n \n16 April 2025
\n \n \n \nA recent study published in the American Journal of Gastroenterology investigates the incidence and survival rates of colorectal cancer (CRC) in the UK. The research offers healthcare decision-makers crucial insights for planning, management and screening for colorectal cancer.
\n \n\n \n \n15 April 2025
\n \n \n \nThe CONSORT 2025 statement, an updated guideline for reporting randomised trials is being simultaneously published in The BMJ, JAMA, The Lancet, Nature Medicine, and PLOS Medicine.
\n \n\n \n \n10 April 2025
\n \n \n \nNDORMS researchers have been awarded funding to explore the long-term effects of burosumab in adults with X-linked hypophosphataemia (XLH).
\n \n\n \n \n9 April 2025
\n \n \n \nEvidence shows for patients with a type of leukaemia, pausing BTKi therapy for COVID-19 vaccination does not improve antibody responses to the vaccine
\n \n\n \n \n7 April 2025
\n \n \n \nA new NDORMS study supports the hypothesis of immunity debt showing increases of influenza rates one year after global relaxation of COVID-19 restrictions. It highlights the need for proactive preparations in future pandemic response strategies.
\n \n\n \n \n2 April 2025
\n \n \n \nThe PROBAST+AI guidelines have been updated to provide clearer, more comprehensive standards for evaluating artificial intelligence (AI) models in healthcare research. Originally introduced to assess the risk of bias and the robustness of prediction models, they have been revised to address the growing importance of AI in healthcare decision-making.
\n \n\n \n \n28 March 2025
\n \n \n \nNew research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKe, play a crucial role in preventing premature cell death, which can lead to serious inflammation in the body. The findings are particularly relevant for people with a mutation in the TBK1 gene who often develop multiorgan inflammation caused by excessive cell death even in the absence of any infection.
\n \n\n \n \n17 March 2025
\n \n \n \nResearchers at the Kennedy Institute have developed a new computational framework that allows simultaneous analysis of gene expression and mechanical forces within cells and tissues, uncovering insights into how the interplay between transcriptional and mechanical signals guides processes such as cell fate decisions or the formation of spatially distinct tissue compartments.
\n \n\n \n \n13 March 2025
\n \n \n \nResearchers at NDORMS have made an important advancement in the field of single-cell transcriptomics by developing a novel bead design that reduces errors in DNA synthesis and improves the reliability of gene expression measurements.
\n \n\n \n \n5 March 2025
\n \n \n \nA new set of guidelines have been launched to create trustworthy AI systems in healthcare. The first of its kind, the FUTURE-AI guideline provides recommendations covering the entire lifecycle of medical AI, from design, development and validation to regulation, deployment, and monitoring.
\n \n\n \n \n27 February 2025
\n \n \n \nA grant from the National Institute for Health and Care Research (NIHR) is funding a study to improve healthcare treatment and care for patients with broken bones in three Sub-Saharan Africa countries.
\n \n\n \n \n13 February 2025
\n \n \n \nThe Translational Pharmacology Group, led by James Fullerton at NDORMS, has announced a significant new partnership with Johnson & Johnson Innovative Medicine to leverage their human experimental medicine platform.
\n \n\n \n \n7 February 2025
\n \n \n \nStudy shows why there are differences in prognosis between different pancreatic tumours and identifies potential avenues for improved treatment approaches.
\n \n\n \n \n4 February 2025
\n \n \n \nA recent study introduces \"Pragmatic Situational Practice Outcomes,\" shedding light on the complexities affecting how patients and healthcare professionals report suspected ADRs related to biologic medications.
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