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Powrie Group | Mucosal Immunology
The Powrie lab employs basic and translational science to study host-microbe crosstalk in health and disease, focussing on inflammatory bowel disease (IBD), colorectal cancer (CRC) and inflammatory arthritis. Research spans observational and functional analysis of a broad range of cell types including bacteria, fibroblasts, T cells and neutrophils.
Arthritis Therapy Acceleration Programme
The Arthritis Therapy Acceleration Programme (A-TAP) creates a hub of expertise and infrastructure to support clinical inflammatory disease research to narrow the gap between bench and bedside.
Arnon Group | Lymphocyte Trafficking and Adaptive Immunity
The main focus of the lab is to understand how humoral immune responses are regulated within the spleen.
Kennedy Translational Innovation Group
We take an interdisciplinary approach from single-molecule imaging to multi-scale computational modelling and experimental validation to identify and develop therapeutic strategies for immune-mediated inflammatory disease.
Buckley Group | Stromal Cell Biology
We aim to uncover the stromal basis of chronic inflammation and related tissue pathology to target fibroblasts across a range of immune-mediated inflammatory diseases.
Johnson Group | Microbiome and Multi-omics
Applying multi-omic and computational genomic approaches to understand the molecular basis of host-microbiome interactions
RIDD
The RIDD trial aims to test whether the progression of Dupuytren’s disease can be halted or slowed by treatment with anti-TNF injection. Currently, Dupuytren’s disease is left to progress until the finger deformity is severe enough to warrant a surgical procedure in hospital. If successful, anti-TNF treatment would prevent loss of hand function and the need for surgery, and would allow patients to be treated conveniently and quickly.
Centre for OA Pathogenesis
Established in 2013, the Centre for Osteoarthritis Pathogenesis Versus Arthritis aims to develop new treatments for this disabling condition, improving healthcare and transforming people's lives.
Itoh Group | Cell Migration
We aim to understand the mechanisms behind uncontrolled cell migration - which promotes progression of certain conditions - to develop new treatments to prevent this progression.
Hand Research Group
We are a collaborative group of academic researchers, therapists, physicians, and surgeons. We carry out a wide range of studies in patients, including observational studies of disease, basic science studies on patient-donated tissue and clinical trials of new treatments. Our ultimate aim is to improve the care of patients with hand and wrist problems.
Sansom Group | Computational and Single Cell Genomics Group
Work in the Sansom lab focuses on identifying the cellular and molecular causes of immune mediated inflammatory disease (IMID) using systems-level approaches.
Fritzsche Group | Biophysical Immunology
Primary research goal is the identification and characterisation of the mechanisms of mechanobiology controlling the immune response in health and disease. Our objectives involve the application and development of novel ultrasensitive live-cell microscopy techniques with the right spatiotemporal sensitivity as demanded by the biology. Long-term goal of our research is the translation of our expertise and methodologies in mechanobiology to mechanomedicine in diagnostics and treatment of patients.
Udalova Group | Genomics of Inflammation
Work in the Udalova Lab is focused on understanding how the inflammatory response is controlled on the molecular level.
Gérard Group | Spatiotemporal Dynamics of T Cell Responses
We are interested in understanding how CD8 T cell responses are organised in space and time to achieve the correct balance between tolerance and immunity.
Bezbradica Mirkovic Group | Innate Immune Sensing in Inflammation
We investigate how innate immune sensing pathways in macrophages control tissue inflammation.
Midwood Group | Matrix Immunology
Our group investigates how the extracellular matrix - the component of tissue that lies immediately outside and between cells - contributes to inflammation.
Vincent Group | Molecular Pathogenesis of Osteoarthritis
Our research focuses on all aspects of osteoarthritis, from understanding its causes to developing new treatments for the condition to improve people's quality of life.