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Anís Gammage

BSc MSc (Oxon)

DPhil Student

Tenascin-C is an extracellular matrix molecule frequently overexpressed in chronic inflammation and cancer. Elevated expression of tenascin-C in breast cancer patients is associated with worsened prognosis, yet the precise pathogenic mechanism underlying this clinical phenotype remains unclear.

My project investigates the immunologic role of tenascin-C in breast cancer using a combination of in vivo models, flow cytometry and computational genomics. Through studying immune cell populations at single-cell resolution, we hope to delineate the mechanism by which tenascin-C contributes to immunosuppression in the tumour microenvironment, and to determine whether this axis might be amenable to therapeutic modulation in breast cancer patients.