Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Anís Gammage

BSc MSc (Oxon)


DPhil Student

Tenascin-C is an extracellular matrix molecule frequently overexpressed in chronic inflammation and cancer. Elevated expression of tenascin-C in breast cancer patients is associated with worsened prognosis, yet the precise pathogenic mechanism underlying this clinical phenotype remains unclear.

My project investigates the immunologic role of tenascin-C in breast cancer using a combination of in vivo models, flow cytometry and computational genomics. Through studying immune cell populations at single-cell resolution, we hope to delineate the mechanism by which tenascin-C contributes to immunosuppression in the tumour microenvironment, and to determine whether this axis might be amenable to therapeutic modulation in breast cancer patients.