Research groups
Brian Marsden
BA (Cantab), MA (Cantab), D.Phil. (Oxon)
Associate Professor, Research Informatics; Associate Head of Medical Sciences Division - Digital and Information
- Chair of University Research Computing Board
Brian is responsible for driving research informatics and research computing capabilities at the Kennedy Institute and the Centre for Medicines Discovery.
After completing a D.Phil. within the Iain Campbell lab at the University of Oxford, Brian was awarded a Wellcome Trust Prize Fellowship which he spent at the Abagyan lab at the Scripps Research Institute, La Jolla, USA, devising novel methods for proteins structure superimposition and also implementing high performance compute and storage clusters. He then worked as part of the Computational Chemistry group at BioFocus PLC before settling down at the SGC in Oxford and now the Centre for Medicines Discovery where he continues to be responsible for all aspects of Informatics, IT and structural bioinformatics. He has a particular interest in the development of novel data capture and visualisation methods for structural and chemical biology data.
Since 2013, Brian has split his time with the Kennedy Institute where he and his team are responsible for the provision of IT capabilities as well as effective data management platforms to support the broad range of science within the Institute.
Key publications
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OOMMPPAA: a tool to aid directed synthesis by the combined analysis of activity and structural data.
Journal article
Bradley AR. et al, (2014), J chem inf model, 54, 2636 - 2646
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SGC--structural biology and human health: a new approach to publishing structural biology results.
Journal article
Lee WH. et al, (2009), Plos one, 4
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A new method for publishing three-dimensional content.
Journal article
Raush E. et al, (2009), Plos one, 4
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ChromoHub: a data hub for navigators of chromatin-mediated signalling.
Journal article
Liu L. et al, (2012), Bioinformatics, 28, 2205 - 2206
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Structural genomics of histone tail recognition.
Journal article
Wang M. et al, (2010), Bioinformatics, 26, 2629 - 2630
Recent publications
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Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical Implications
Journal article
Aschenbrenner D. et al, (2022), Journal of clinical immunology
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COMBATdb: a database for the COVID-19 Multi-Omics Blood ATlas.
Journal article
Wang D. et al, (2022), Nucleic acids res
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SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection
Journal article
POUWELS K. et al, (2022), Nature communications
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Antibody responses and correlates of protection in the general population after two doses of the ChAdOx1 or BNT162b2 vaccines.
Journal article
Wei J. et al, (2022), Nat med, 28, 1072 - 1082
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FAS2FURIOUS: Moderate-throughput secreted expression of difficult recombinant proteins in Drosophila S2 cells
Journal article
MIDWOOD KIM. et al, (2022), Frontiers in bioengineering and biotechnology, section synthetic biology