Websites
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Schofield Group
Chemistry Research Laboratory | Department of Chemistry
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Structural Genomics Consortium
Research Group
Catrine Johansson
Senior Postdoctoral Research Associate
Catrine Johansson
MSc, PhD
Catrine Johansson earned her PhD in Biochemistry at Karolinska Institutet where she was involved in the characterisation of glutaredoxins, enzymes involved in oxidative stress, thiol redox signalling and iron-sulfur biogenesis. In January 2005, Catrine joined the Biotechnology group at Structural Genomics Consortium (SGC) in Oxford to develop and implement methodologies for high throughput crystallization of human proteins. In 2007, she moved to Prof. Oppermann’s biology group at the SGC to focus on the structural characterisation human thiol-disulfide oxidoreductases. In July 2011, Catrine joined the epigenetic project at the SGC aiming to develop potent and selective small molecule inhibitors of proteins involved in epigenetic processes. In this role Catrine had the responsibility for the crystallisation of JmjC lysine demethylases (KDMs), “erasers” that act to remove methyl groups from histone tails as well as some Tudor domain containing proteins, “readers” that recognise methyl marks.
Catrine moved to Prof. Oppermann's group at the Botnar Research Centre in August 2015, where she in a joint position with the Chemistry Department continues the structural and biochemical characterisation of KDMs. Her research aims to provide detailed aspects of KDM substrate recognition and to identify stimuli that may regulate their activity. Catrine is also involved in several structure-based drug development programs aimed to develop potent and selective inhibitors towards various cancer related proteins.
Recent publications
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Journal article
Fagan V. et al, (2019), J med chem, 62, 9008 - 9025
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Journal article
Xiong Y. et al, (2019), J med chem, 62, 8996 - 9007
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Journal article
Giordano A. et al, (2019), Acs med chem lett, 10, 601 - 605
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Journal article
Pfeiffer M. et al, (2019), Acs catal, 9, 2962 - 2968
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Journal article
Giordano A. et al, (2018), Chemmedchem, 13, 1160 - 1164