Catrine Johansson

• Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

  Tumber A. et al, (2017), Cell chemical biology, 24, 371 - 380

• Advances and challenges in understanding histone demethylase biology.

  Nowak RP. et al, (2016), Current opinion in chemical biology, 33, 151 - 159

• Structural analysis of human KDM5B guides histone demethylase inhibitor development.

  Johansson C. et al, (2016), Nature chemical biology, 12, 539 - 545

• 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

  Bavetsias V. et al, (2016), Journal of medicinal chemistry, 59, 1388 - 1409

• Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.

  Carr SM. et al, (2014), Proceedings of the National Academy of Sciences of the United States of America, 111, 11341 - 11346

• Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.

  Walport LJ. et al, (2014), The Journal of biological chemistry, 289, 18302 - 18313

• The roles of Jumonji-type oxygenases in human disease.

  Johansson C. et al, (2014), Epigenomics, 6, 89 - 120

• An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin

  Bräutigam L. et al, (2013), Biochemical and Biophysical Research Communications, 436, 491 - 496

• An unusual mode of iron-sulfur-cluster coordination in a teleost glutaredoxin.

  Bräutigam L. et al, (2013), Biochemical and biophysical research communications, 436, 491 - 496

• The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity.

  Johansson C. et al, (2011), The Biochemical journal, 433, 303 - 311

• RhoB can adopt a Mg2+ free conformation prior to GEF binding.

  Soundararajan M. et al, (2008), Proteins, 72, 498 - 505

• High throughput production of recombinant human proteins for crystallography.

  Gileadi O. et al, (2008), Methods in molecular biology (Clifton, N.J.), 426, 221 - 246

• Redox properties and evolution of human glutaredoxins.

  Sagemark J. et al, (2007), Proteins, 68, 879 - 892

• Oxidation and S-nitrosylation of cysteines in human cytosolic and mitochondrial glutaredoxins: effects on structure and activity.

  Hashemy SI. et al, (2007), The Journal of biological chemistry, 282, 14428 - 14436

• The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43.

  Porat A. et al, (2007), Biochemistry, 46, 3366 - 3377

• Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.

  Johansson C. et al, (2007), The Journal of biological chemistry, 282, 3077 - 3082

• Thiol redox control via thioredoxin and glutaredoxin systems.

  Holmgren A. et al, (2005), Biochemical Society transactions, 33, 1375 - 1377

• Human Mitochondrial Glutaredoxin Reduces S -Glutathionylated Proteins with High Affinity Accepting Electrons from Either Glutathione or Thioredoxin Reductase

  Johansson C. et al, (2004), Journal of Biological Chemistry, 279, 7537 - 7543

• Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity.

  Jiménez A. et al, (2002), FEBS letters, 530, 79 - 84

• Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency.

  Porras P. et al, (2002), Biochemical and biophysical research communications, 295, 1046 - 1051

• Cloning and Expression of a Novel Human Glutaredoxin (Grx2) with Mitochondrial and Nuclear Isoforms

  Lundberg M. et al, (2001), Journal of Biological Chemistry, 276, 26269 - 26275

Recent Publications

• Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

  Tumber A. et al, (2017), Cell chemical biology, 24, 371 - 380

• Advances and challenges in understanding histone demethylase biology.

  Nowak RP. et al, (2016), Current opinion in chemical biology, 33, 151 - 159

• Structural analysis of human KDM5B guides histone demethylase inhibitor development.

  Johansson C. et al, (2016), Nature chemical biology, 12, 539 - 545

• 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

  Bavetsias V. et al, (2016), Journal of medicinal chemistry, 59, 1388 - 1409

• Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.

  Carr SM. et al, (2014), Proceedings of the National Academy of Sciences of the United States of America, 111, 11341 - 11346