- Griseri Group | Haematopoiesis and Chronic Inflammation Research Group
Postdoctoral Research Fellow
I completed my DPhil in the laboratory of Professor David Greaves at the Sir William Dunn School of Pathology, Oxford where I was funded by the British Heart Foundation. My research focused on the role played by chemokines and macrophages in chronic inflammation and how they might contribute to its resolution.
I joined the Kennedy Institute of Rheumatology in 2016 to work as a postdoctoral researcher in Dr. Thibault Griseri's laboratory. My research focuses on the mechanisms by which dysregulation of haematopoietic stem cells and myeloid cell progenitors drive disease during inflammatory arthritis.I am particularly interested in the migration of myeloid cell progenitors from the bone marrow to local sites of inflammation.
In addition, I am investigating the role played by the microbiota in the regulation of myelopoiesis during arthritis.
RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling.
Patel J. et al, (2015), Nature communications, 6
McNeill E. et al, (2014), J Mol Med (Berl), 92, 1169 - 1178
Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.
Iqbal AJ. et al, (2014), Blood, 124, e33 - e44
Murine Chemerin (T-20-S-156) enhances the resolution of inflammation in a murine model of zymosan induced peritonitis
Regan-Komito D. et al, (2014), EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 44, 26 - 26
Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells.
Greene LM. et al, (2013), International journal of oncology, 43, 927 - 935