Advanced Tissue Pathology SRF Lead
I am the Research Facility Lead for the Advanced Tissue Pathology SRF, which includes the Cell DIVE Multiplex Imaging system and OTLS system (arriving Q3 2022).
After studying Biomedical Science at the University of Surrey, I completed a BBSRC iCASE PhD at the University of Exeter focusing on the effect of nanoparticles in zebrafish using light sheet microscopy. This is where my passion for microscopy began, as I built an OpenSPIM system to quantify fluorescently tagged nanoparticles in whole zebrafish embryos. I then worked at Cambridge University using imaging and the zebrafish model to undertake an extensive drug screen to investigate disease mechanisms in MSD (Multiple Sulfatase Deficiency).
Since joining the Kennedy Institute of Rheumatology (KIR), I have set up the Cell DIVE imaging facility, supporting both users from the University of Oxford and visiting scientists from across the world (including Brazil and Germany). I support the Director of Clinical Sciences, Professor Christopher Buckley with a remit to support tissue pathology across the Kennedy Institute, Department of Oncology, Wellcome Centre for Human Genomics, and the new Institute for Developmental and Regenerative Medicine. I now focus on further developing new protocols from my research and pushing forward the frontiers in multiplex imaging as well as improving existing protocols and technologies. I also help support the imaging facility at KIR and the Oxford-Zeiss Centre of Excellence.
Primed to resolve: A single cell atlas of the shoulder capsule reveals a cellular basis for resolving inflammatory fibrosis
Ng MTH. et al, (2023)
Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.
Korsunsky I. et al, (2022), Med (n y), 3, 481 - 518.e14
Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency.
Fleming A. et al, (2022), Frontiers in cell and developmental biology, 10
4-dimensional functional profiling in the convulsant-treated larval zebrafish brain.
Winter MJ. et al, (2017), Scientific reports, 7