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Edward Samuel Hookway


Postdoctoral Researcher

My research focuses on epigenetic mechanisms in both primary bone cancer, especially Ewing Sarcoma, and cancer that affects bone such as multiple myeloma. I use a range of traditional molecular biology and cell culture techniques and am developing an interesting in the application of Next Generation Sequencing technologies to answer fundamental questions about the epigenetic driving factors involved in cancer development. Working in collaboration with Prof Ulrich Guenther, University of Birmingham, I use Nuclear Magnetic Resonance technology to study cell metabolism its perturbation in cancer.

EDUCATION

  • DPhil University of Oxford 2012-present
  • MA University of Oxford 2012
  • MA University of Cambridge 2009
  • MB BChir Medicine and Surgery, University of Cambridge 2008
  • BA (Hons) Natural Sciences (Pharmacology) , University of Cambridge 2005
  • MRCP Royal College of Physicians 2011

PROFESSIONAL EXPERIENCE

After qualifying in medicine from Gonville and Caius College, University of Cambridge, I worked as a doctor in the NHS in both East Anglia and London. I spent time working in the cancer unit of Addenbrooke's Hospital, Cambridge and the Royal Marsden Hospital in London before returning to the labs to focus on the basic science underlying cancer development and treatment.

INVITED TALKS/CONFERENCE PRESENTATIONS

  1. “Epigenetic target validation in sarcoma and bone oncology”, 6th  International Workshop on Advances in the Molecular Pharmacology and Therapeutics of Bone and other Musculoskeletal Disease, Oxford, UK, July 2014
  2. “Epigenetics and metabolism in multiple myeloma”, Euro Bio-NMR, Warsaw, Poland, May 2014
  3. “The role of the lysine demethylase KDM5B and KDM6 in the Ewing sarcoma family of tumours”, European Musculo-Skeletal Oncology Society conference, Vienna, Austria, May 2014
  4. “Epigenetics and bone cancer”, Bone Cancer Research Trust 8th annual patient and supporters conference, Bristol, UK, October 2013
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Recent Publications

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