Contact information
Research groups
Elizabeth Mann
Postdoc Researcher in Colorectal Cancer
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths world-wide, for which a variety of genetic and environmental risk factors are known to exist. One molecule that is known to promote CRC in mouse models of disease is the Th17-family cytokine IL-23. In human CRC, levels of IL-23 are similarly elevated but it's function in disease progression remains poorly understood.
My research aims to uncover what drives the enhanced production of IL-23 in human CRC tumours and what it is doing at a molecular level. Insights from these studies will hopefully inform the development of novel diagnostic assays and therapeutics for CRC, particularly focusing on subsets of patients that have poor prognosis.
Key publications
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Journal article
Cavounidis A. and Mann EH., (2020), Nat rev immunol
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Journal article
McCuaig S. et al, (2020), Clin cancer res
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Journal article
Mann EH. et al, (2019), The journal of immunology, 202, 684 - 693
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Journal article
Mann EH. et al, (2014), Annals of the new york academy of sciences, 1317, 57 - 69
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Journal article
Mann EH. et al, (2017), American journal of respiratory cell and molecular biology, 57, 355 - 366
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Journal article
Sapey E. et al, (2014), Blood, 123, 239 - 248