Autophagy and Immune Senescence
Autophagy is impaired during ageing in multiple systems including immune cells, which contributes to cellular senescence and the pathogenesis of many age-related diseases. I am interested in
a) The mechanism of autophagy dysfunction during ageing,
b) How impaired autophagy leads to immune senescence, and
c) If immune senescence could be reversed by autophagy induction.
Zhang H. et al, (2016), Trends in molecular medicine, 22, 671 - 686
Puleston DJ. et al, (2014), eLife, 3