Krista Adelmann
POSTDOCTORAL RESEARCHER
My work as a DPhil student is jointly supervised by Fiona Powrie and Graham Ogg and reflects the common interests of both groups in investigating immune function at barrier surfaces of the body.
My project investigates the role of regulatory T cells in the skin by taking advantage of the experimental models available in the Powrie lab and the access to human skin samples in the Ogg lab.
I seek to delineate the importance of FoxP3+ T cells in inflammatory skin disease with a particular emphasis on psoriasis and murine models of psoriasiform skin inflammation.
Recent publications
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Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8+ T cell response.
Journal article
Stockenhuber K. et al, (2018), J exp med, 215, 1987 - 1998
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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.
Journal article
West NR. et al, (2017), Nat med, 23, 579 - 589
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Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling.
Journal article
Ilott NE. et al, (2016), Isme j, 10, 2389 - 2404
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T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.
Journal article
Krausgruber T. et al, (2016), Nat commun, 7
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The alarmin IL-33 promotes regulatory T-cell function in the intestine.
Journal article
Schiering C. et al, (2014), Nature, 513, 564 - 568