Oxford Celgene Fellow
I am a postdoctoral fellow working with Mark Coles at the Kennedy Institute and Eamonn Gaffney at the Mathematical Institute. I work in collaboration with Celgene.
My research interests lie in cancer immunology, particularly in T-cell therapeutics. I am interested in using quantitative (mathematical and computational) techniques to constrain our knowledge of biological mechanisms and processes, and quantify how these may differ between mice and humans.
For example, lymphatic drainage times are five-fold faster in mice than humans. Could this therefore lead to a difference in how mouse models and patients may respond to a therapeutic given intradermally, if the therapeutic has a known half-life in the body?
To see more, please visit my website on the mathematics website.
Applications of mechanistic modelling to clinical and experimental immunology: an emerging technology to accelerate immunotherapeutic discovery and development
Brown LV. et al, (2018), Clinical & experimental immunology, 193, 284 - 292
model of cytotoxic T-lymphocyte activation in the lymph node following short peptide vaccination
Brown LV. et al, (2018), Journal of the royal society interface, 15, 20180041 - 20180041