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Research groups

Ling Felce

MBiochem, DPhil

Postdoctoral Researcher in Cell and Molecular Biology

I completed my DPhil in Clinical Pharmacology from the Department of Oncology, University of Oxford, where the focus of my thesis was the production and testing of B-cell targeting cancer vaccines based on different viral vectors. During the course of my research, I became interested in cancer immunology and the tumour microenvironment.

My first postdoctoral project was undertaken with Professor Alison Banham (NDCLS/RDM) where I investigated the targets of transcription factor FOXP1 in diffuse large B-cell lymphoma (DLBCL). In patients with DLBCL, FOXP1 can be used as a marker for poor prognosis, and may play a role in downregulating immune surveillance in tumours. I used CRISPR-Cas9 gene editing technology to knockout FOXP1 expression in a murine lymphoma cell line, and subsequently conducted tumour studies in vivo and carried out RNA-Seq to examine differential gene expression between parental and FOXP1-knockout cells.

In 2017 I joined Dr Gillian Farnie’s group at the Botnar Research Centre, where my research is focused on novel protein families, such as the YEATS family in cancer, as well as developing cellular assays to characterise and validate chemical probes. I am currently looking into the role of MLLT1 histone reader in breast cancer by altering MLLT1 protein levels/function through CRISPR-Cas9 knockouts and small molecule inhibition, and using next generation sequencing (RNA-Seq and ChIP-Seq) to understand how MLLT1 alters global gene expression to drive tumourigenesis and metastasis in breast cancer. I am also involved in a multi-collaborative effort to develop novel small molecule inhibitors targeting MLLT1 in acute leukaemia.

Key publications

Recent publications

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