- Horwood Group | Osteoimmunology Research Group
BSc Hons, DPhil (Oxford)
Senior Research Associate in Osteoimmunology
Inflammatory and autoimmune diseases often show pathologies in bone and bone metabolism. Further work is needed to understand whether such observations are due to direct effects of immune cells on bone cells, or due to inflammation having bystander effects on bone cells. Unravelling such entwined processes is a key feature of osteoimmunology research.
RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation.
Danks L. et al, (2016), Annals of the rheumatic diseases, 75, 1187 - 1195
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Guerrini MM. et al, (2015), Immunity, 43, 1174 - 1185
Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.
Takaba H. et al, (2015), Cell, 163, 975 - 987
Ersek A. et al, (2015), The Journal of clinical investigation, 125, 2279 - 2292
Gwyer Findlay E. et al, (2014), Proceedings of the National Academy of Sciences of the United States of America, 111, 2289 - 2294