Matteo Vecellio

• Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis.

  Wordsworth BP. et al, (2017), Proceedings of the National Academy of Sciences of the United States of America, 114

• ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations.

  Roberts AR. et al, (2017), Proceedings of the National Academy of Sciences of the United States of America, 114, 558 - 561

• An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.

  Roberts AR. et al, (2016), Annals of the rheumatic diseases, 75, 2150 - 2156

• The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

  Vecellio M. et al, (2016), Annals of the rheumatic diseases, 75, 1534 - 1540

• Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

  Picaud S. et al, (2015), Cancer research, 75, 5106 - 5119

• CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

  Hammitzsch A. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 10768 - 10773

• The histone acetylase activator pentadecylidenemalonate 1b rescues proliferation and differentiation in the human cardiac mesenchymal cells of type 2 diabetic patients.

  Vecellio M. et al, (2014), Diabetes, 63, 2132 - 2147

• FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS

  Vecellio ML. et al, (2014), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 32, 819 - 819

• ANKYLOSING SPONDYLITIS-ASSOCIATED SNPS AT THE IL23R-IL12RB2 INTERGENIC REGION ARE FUNCTIONALLY IMPORTANT

  Roberts AR. et al, (2014), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 32, 819 - 819

• Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia.

  Spallotta F. et al, (2013), The Journal of biological chemistry, 288, 22915 - 22929

• Human chorionic villus mesenchymal stromal cells reveal strong endothelial conversion properties.

  Meraviglia V. et al, (2012), Differentiation; research in biological diversity, 83, 260 - 270

• In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors.

  Vecellio M. et al, (2012), PloS one, 7

• Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.

  Giannandrea M. et al, (2010), American Journal of Human Genetics, 86, 185 - 195

• Cognitive impairment in Gdi1-deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training.

  Bianchi V. et al, (2009), Human molecular genetics, 18, 105 - 117

Key Publications

• The histone acetylase activator pentadecylidenemalonate 1b rescues proliferation and differentiation in the human cardiac mesenchymal cells of type 2 diabetic patients.

  Vecellio M. et al, (2014), Diabetes, 63, 2132 - 2147

• CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

  Hammitzsch A. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 10768 - 10773

• In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors.

  Vecellio M. et al, (2012), PloS one, 7

• Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia.

  Spallotta F. et al, (2013), The Journal of biological chemistry, 288, 22915 - 22929

• The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

  Vecellio M. et al, (2016), Annals of the rheumatic diseases, 75, 1534 - 1540

Recent Publications

• Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis.

  Wordsworth BP. et al, (2017), Proceedings of the National Academy of Sciences of the United States of America, 114

• ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations.

  Roberts AR. et al, (2017), Proceedings of the National Academy of Sciences of the United States of America, 114, 558 - 561

• An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.

  Roberts AR. et al, (2016), Annals of the rheumatic diseases, 75, 2150 - 2156

• The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

  Vecellio M. et al, (2016), Annals of the rheumatic diseases, 75, 1534 - 1540

• Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.

  Picaud S. et al, (2015), Cancer research, 75, 5106 - 5119