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Matteo Vecellio


Versus Arthritis Career Development Fellow

Ankylosing Spondylitis (AS) is an inflammatory arthritis with numerous robust genetic associations.

My research goal is to investigate the epigenetic mechanisms by which RUNX3 gene contribute to AS, deciphering how RUNX3 genetic variants (SNPs) alter transcriptional regulation and affect CD8+ T-cell compartment. I'm trying to assess the impact of disrupted transcriptional regulation for AS patients and gain new insight into disease pathogenesis.

I joined the Lab of Professor Wordsworth at NDORMS, in June 2013. Previously, I received my PhD degree in Translational and Molecular Medicine in 2012 from the University of Milan – Bicocca (Italy). Soon after my Ph.D I spent one year at the Goethe University in Frankfurt-am-Main (Germany), carrying on the work started during the Ph.D period focused on the epigenetic regulation of human cardiac mesenchymal stromal cells.

I've been recently awarded with a 5 years Arthritis Research UK Career Development Fellowship to decipher the RUNX3 role in AS.

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