Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Matteo Vecellio


Versus Arthritis Career Development Fellow/Junior PI

RUNX3 regulation in Ankylosing Spondylitis

Ankylosing Spondylitis (AS) is an inflammatory arthritis with numerous robust genetic associations.

The goal of the group is to investigate the epigenetic mechanisms by which RUNX3 gene contribute to AS, deciphering how RUNX3 genetic variants (SNPs) alter transcriptional regulation and affect CD8+ T-cell compartment. We aim to assess the impact of disrupted transcriptional regulation for AS patients and gain new insight into disease pathogenesis.

I joined the Lab of Professor Wordsworth at NDORMS, in June 2013. Previously, I received my PhD degree in Translational and Molecular Medicine in 2012 from the University of Milan – Bicocca (Italy). Soon after my Ph.D I spent one year at the Goethe University in Frankfurt-am-Main (Germany), carrying on the work started during the Ph.D period focused on the epigenetic regulation of human cardiac mesenchymal stromal cells.

I've been  awarded in 2017 with a 5 years Arthritis Research UK Career Development Fellowship. Our recent work has been recognized with the Garrod Award 2021- Excellence in Rheumatology Research from the British Society of Rheumatology