Versus Arthritis Career Development Fellow/Junior PI
RUNX3 regulation in Ankylosing Spondylitis
Ankylosing Spondylitis (AS) is an inflammatory arthritis with numerous robust genetic associations.
The goal of the group is to investigate the epigenetic mechanisms by which RUNX3 gene contribute to AS, deciphering how RUNX3 genetic variants (SNPs) alter transcriptional regulation and affect CD8+ T-cell compartment. We aim to assess the impact of disrupted transcriptional regulation for AS patients and gain new insight into disease pathogenesis.
I joined the Lab of Professor Wordsworth at NDORMS, in June 2013. Previously, I received my PhD degree in Translational and Molecular Medicine in 2012 from the University of Milan – Bicocca (Italy). Soon after my Ph.D I spent one year at the Goethe University in Frankfurt-am-Main (Germany), carrying on the work started during the Ph.D period focused on the epigenetic regulation of human cardiac mesenchymal stromal cells.
I've been awarded in 2017 with a 5 years Arthritis Research UK Career Development Fellowship. Our recent work has been recognized with the Garrod Award 2021- Excellence in Rheumatology Research from the British Society of Rheumatology
Motta F. et al, (2021), Curr rheumatol rep, 23
Vecellio M. et al, (2020), Clin rheumatol
Watts L. et al, (2019), Genes immun, 20, 167 - 171
Frischknecht L. et al, (2019), Ther adv musculoskelet dis, 11
OP0231?Differential transcription factor binding could explain the genetic association of ankylosing spondylitis with polymorphisms in the IL23R-IL12RB2 intergenic region
(2018), Annals of the rheumatic diseases