- Itoh Group | Cell Migration Research Group
Dr Mayank Chaturvedi is postdoctoral researcher in cell migration research group at Kennedy Institute of Rheumatology, University of Oxford.
In 2014, He received PhD in neurobiology from Nencki Institute, Polish Academy of Sciences, Warsaw Poland. During PhD, he developed PLGA nanoparticles for brain delivery of TIMP-1 and showed its neuroprotective effects. He received PhD with distinction and was nominated for Prime Minister’s prize in Poland by Nencki Institute for best doctoral dissertation (2014).
By training he is pharmacist, he received master’s degree in pharmaceutical sciences from Dr H. S. Gour University, Sagar, India. After masters degree, he worked as lecturer in Vivekanand College of pharmacy, Indore India for three years.
- MMPs (in particular MMP-9 and MMP-14) in cellular function and dysfunction.
- Application of nanoparticulate systems for protein / gene and other bioactives delivery in CNS disorders and using them to explore molecular basis of memory.
- Wireless neural stimulation.
Currently, he is working on MT1-MMP (Membrane Type -1 Matrix MetalloProteinase or MMP-14) which is highly implicated in development of various human cancers and rheumatoid arthritis, where cellular invasion is a hallmark. MT1-MMP degrades pericellular extracellular matrix (ECM) and makes a path for invading cells. To promote cellular invasion, MT1-MMP must localize to the leading edge of the invading cells i.e. lamellipodia, filopodia and invadopodia. However, the precise mechanism of how MT1-MMP is localized to the leading edge of migrating/invading cells, is not yet understood. Therefore, he is interested to understand the molecular mechanisms of MT1-MMP localization to the functional leading edge of invading cells.
Mmp-9 inhibition: a therapeutic strategy in ischemic stroke.
Chaturvedi M. and Kaczmarek L., (2014), Molecular neurobiology, 49, 563 - 573
Tissue inhibitor of matrix metalloproteinases-1 loaded poly(lactic-co-glycolic acid) nanoparticles for delivery across the blood-brain barrier.
Chaturvedi M. et al, (2014), International journal of nanomedicine, 9, 575 - 588
Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala.
Knapska E. et al, (2013), The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, 14591 - 14600
Chaturvedi M. et al, (2012), Neurochemistry international, 61, 1065 - 1071
Key Awards and Achievements
MAJOR GRANTS & FELLOWSHIPS
- “Mobility Plus” grant from Polish Ministry of Science and Higher Education for post-doc (2015-17).
- “Preludium” grant from National Science Centre of Poland (2014-15).
- PhD studentship at Nencki Institute funded by Foundation for Polish Science (2010-13)
MAJOR AWARDS & NOMINATIONS
- Nominated for Prime Minister’s prize in Poland by Nencki Institute for best doctoral dissertation (2014).
- Best talk award in FEBS Young Scientist Forum, Paris, France (2014).
- Best talk award during annual PhD students’ presentations at Nencki Institute, Poland (2012).
- Short term stay grants: From IBRO’s Young Investigator Training Program for working National Laboratory for Embryonic Stem Cell Research, Rio de Janeiro, Brazil and from eCOST for working in Vect-Horus (a French biotechnology company) Marseille, France.
- Travel Grants: 13 travel awards from various societies including: RIKEN, Japanese Neuroscience Society, British Neuroscience Society, IBRO, ISN, FENS, FEBS, EMBO, European Foundation for Nanomedicine etc.
- Conferences: 8 talks and in 14 posters in all major Neuroscience and Nanomedicine conferences.