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Milan M. Fowkes

MChem (Warwick); MSc (Western); AMRSC


DPhil Student

Designing selective ADAMTS-4,-5 substrates to detect and image proteinase activity in vivo

I did my undergraduate master's degree in Chemistry (MChem) at the University of Warwick (2007-2011), where I worked on a final year project involving radical cyclisations of N-alkenyl-N-2-bromobenzyl acetamides under the supervision of Dr. Andrew Clark. I moved to Canada in 2012, and under the guidance of Dr. Leonard G. Luyt I completed a two-year MSc in Chemistry at Western university with a specialisation in molecular imaging. During that time, I synthesised a peptidomimetic radiotracer specifically targeting the ghrelin receptor for the purpose of PET imaging of prostate cancer. Having developed a strong interest in molecular imaging, I began working as a research assistant on a collaborative project between the Kennedy Institute (Dr. Ngee Han Lim) and Target Discovery Institute (Professor Paul E. Brennan) at the University of Oxford in 2015. This involved synthesising a series of radiopaque peptides for imaging cartilage breakdown in osteoarthritis. I began my DPhil in October 2016, and my current research focuses on designing selective ADAMTS-4,-5 substrates to detect and image their proteinase activity in vivo. I am supervised by Dr. Ngee Han Lim (Kennedy) as well as Professor Tonia L. Vincent (Kennedy) and Professor Paul E. Brennan (TDI).

 

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