Ngee Han Lim
KTRR/ARUK Research Fellow & NDORMS Undergraduate Research Coordinator
I was a Biochemistry undergraduate at Corpus Christi College, Oxford. My PhD training was with Prof. Hideaki Nagase at Imperial College, London, developing mutants of tissue inhibitor of metalloproteinases (TIMP)-3 to be selective for the aggrecanses over the matrix metalloproteinases (MMPs) and using these mutants to determine the relative contributions of the enzymes in in vitro models of disease.
My post-doctoral work looked at developing selective substrates tagged with near-infrared fluorophores to follow MMP activity during the development of arthritis in in vivo models of disease using non-invasive optical imaging.
I further developed my non-invasive optical imaging skills in Dr. Ahuva Nissim’s laboratory, using the technique to determine if an antibody specific for type II collagen damaged by reactive oxygen species could be used to detect early osteoarthritis in a surgical model of disease.
In October 2014 I joined the Kennedy Institute as an ARUK/KTRR Research Fellow within the ARUK Centre for Osteoarthritis Pathogenesis to develop novel in vivo imaging tools for osteoarthritis..
D-Net: An AI model for aligning volumes, developed for cartilage segmentation from CT scans contrasted with a type II collagen binding peptide containing di-iodotyrosine
Zheng JQ. et al, (2021), International journal of experimental pathology, 102, 134 - 135
Lim NH. et al, (2020), Osteoarthritis cartilage, 28, 874 - 884
Zheng J-Q. et al, (2020), Shape in Medical Imaging, 73 - 84
Fowkes M. and Lim NH., (2019), ADAMTS Proteases, 2043, 75 - 91
Duro‐Castano A. et al, (2018), Advanced functional materials