Contact information
Nicole Yager
Postdoctoral Research Assistant in Immunology
I joined the Bowness group in 2017, and have been investigating the immune response in psoriatic arthritis (PsA), with a keen interest in cytometry techniques and analysis. I am currently involved in the OPTIMISE (Optimising Psoriatic Arthritis Therapy with Immunological Methods to Increase Standard Evaluation) clinical study which will test whether we can predict if PsA patients with high Th17 cells predicts response to biologic drugs.
In addition, I am currently in charge of managing the BD LSRFortessa flow cytometer that is located in the Botnar Research Centre.
Previously, I completed my DPhil at the Peter Medawar Building for Pathogen Research, with a focus on HIV-1 immunology. I then worked at the University of Southampton as a postdoctoral research fellow with an interest in psoriasis.
Recent publications
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Ex vivo mass cytometry analysis reveals a profound myeloid proinflammatory signature in psoriatic arthritis synovial fluid.
Journal article
Yager N. et al, (2021), Ann rheum dis
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Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.
Journal article
Penkava F. et al, (2020), Nat commun, 11
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Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele.
Journal article
Al-Mossawi H. et al, (2019), Nat commun, 10
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Expression of PI3K Signaling Associated with T Cells in Psoriasis Is Inhibited by Seletalisib, a PI3Kδ Inhibitor, and Is Required for Functional Activity
Journal article
YAGER NL. et al, (2018), Journal of investigative dermatology, 138, 1435 - 1439
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Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.
Journal article
Al-Mossawi MH. et al, (2017), Nat commun, 8