Contact information
LOCATION
Botnar Research Centre, Old Road, Headington, Oxford, OX3 7LD
Parisa Sinai
Clinical Trial Manager – DISCUS
I joined SITU as Clinical Trial Manager for DISCUS in January 2021. DISCUS is a randomised controlled trial for traumatic spinal cord injury (TSCI) set in trauma/emergency units. It compares surgery including laminectomy plus duroplasty (intervention) to surgery including laminectomy, with an integrated QuinteT Recruitment Intervention (QRI). DISCUS has a mechanistic laboratory substudy investigating mechanism. DISCUS aims to recruit 222-260 participants (UK-international).
Prior to DISCUS, I worked in trial management positions in multicentre surgery randomised controlled trials (RCTs) (breast surgery, orthopaedic, urology), paediatric RCTs (ophthalmology, chronic fatigue) and drug trial (CTIMP- immunotherapy for Diabetes Type 1) – supported by UKCRC registered trial units in Swansea and in Bristol. My last position was a senior research associate/trial manager post to set up and recruit for a breast surgery trial and I coordinated a public health paediatric ophthalmology feasibility study set in schools (at University of Bristol). Previous to this, I held trial management/research projects manager positions in Bristol Randomised Trials Collaboration (BRTC- now BTC), the NHS Bristol, North Somerset and South Gloucestershire Clinical Commissioning Group (BNSSG CCG) and Cardiff University.
My interest in translational clinical research and trials stems from my earlier career as an academic researcher working on drugs in autoimmune disease and cancer in the laboratory. I hold a BSc from University of California at Berkeley in Molecular Cell Biology and a PhD in immunology from University of Texas Southwestern Medical Centre at Dallas in USA.
Recent publications
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Improving outcomes for primary school children at risk of cerebral visual impairment (the CVI project): protocol of a feasibility study for a cluster-randomised controlled trial and health economic evaluation
Journal article
Williams C. et al, (2021), Bmj open, 11, e044830 - e044830
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Recovery from chronic fatigue syndrome: a systematic review—heterogeneity of definition limits study comparison
Journal article
Moore Y. et al, (2021), Archives of disease in childhood
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A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability
Journal article
Li Y. et al, (2021), Cells, 10, 418 - 418
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Corrigendum to An international update of the EORTC questionnaire for assessing quality of life in breast cancer patients: EORTC QLQ-BR45
Journal article
Bjelic-Radisic V. et al, (2020), Annals of oncology, 31, 552 - 552
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International validation of the European Organisation for Research and Treatment of Cancer QLQ-BRECON23 quality-of-life questionnaire for women undergoing breast reconstruction.
Journal article
Winters ZE. et al, (2018), Br j surg, 105, 209 - 222
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T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice
Journal article
Sinai P. et al, (2014), European journal of immunology, 44, 3522 - 3531
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The actin-driven spatiotemporal organization of T-cell signaling at the system scale
Journal article
Roybal KT. et al, (2013), Immunological reviews, 256, 133 - 147
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Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy
Journal article
Sinai P. et al, (2010), Communicative & integrative biology, 3, 545 - 548
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Somatic Expression of PyMT or Activated ErbB2 Induces Estrogen-Independent Mammary Tumorigenesis
Journal article
Toneff MJ. et al, (2010), Neoplasia, 12, 718 - IN2
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Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42
Journal article
Sinai P. et al, (2010), Proceedings of the national academy of sciences, 107, 11912 - 11917