Raphael Sanches Peres

PhD

Postdoctoral Researcher

PhD in Immunology at University of São Paulo-Brazil studying the mechanisms associated with methotrexate resistance in patients with rheumatoid arthritis. I joined to the Fiona Powrie’s group at the Kennedy Institute of Rheumatology in 2017 granted with an EMBO Long-Term Fellowship.

My research investigates the contribution of regulatory T (Treg) cell to the maintenance of the immunological homeostasis as well as the events linked to Tregs biology that have impact on the development, establishment, and resolution of chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. In general, my interest is to develop novel therapeutic strategies for inflammatory diseases focused on the manipulation of Tregs function and determine how this cell population may influence in the efficacy of therapeutic agents available in the clinic, such as methotrexate and TNF inhibitors.

Recent publications

Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis
Journal article

SANCHES PERES R., (2020), Proceedings of the national academy of sciences of usa
TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions.
Journal article

Leng T. et al, (2019), Cell rep, 28, 3077 - 3091.e5
TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism.
Journal article

de Lima KA. et al, (2018), Cell death dis, 9
Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes.
Journal article

Saraiva AL. et al, (2018), Faseb j
Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells.
Journal article

Talbot J. et al, (2018), Arthritis res ther, 20

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