Contact information
Research groups
Raphael Sanches Peres
PhD
Postdoctoral Researcher
PhD in Immunology at University of São Paulo-Brazil studying the mechanisms associated with methotrexate resistance in patients with rheumatoid arthritis. I joined to the Fiona Powrie’s group at the Kennedy Institute of Rheumatology in 2017 granted with an EMBO Long-Term Fellowship.
My research investigates the contribution of regulatory T (Treg) cell to the maintenance of the immunological homeostasis as well as the events linked to Tregs biology that have impact on the development, establishment, and resolution of chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. In general, my interest is to develop novel therapeutic strategies for inflammatory diseases focused on the manipulation of Tregs function and determine how this cell population may influence in the efficacy of therapeutic agents available in the clinic, such as methotrexate and TNF inhibitors.
Recent publications
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Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis
Journal article
SANCHES PERES R., (2020), Proceedings of the national academy of sciences of usa
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Journal article
Leng T. et al, (2019), Cell rep, 28, 3077 - 3091.e5
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Journal article
de Lima KA. et al, (2018), Cell death dis, 9
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Journal article
Saraiva AL. et al, (2018), Faseb j
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Journal article
Talbot J. et al, (2018), Arthritis res ther, 20