Ruth Knight
MMath, PhD
Senior Medical Statistician
I contribute statistical expertise to the design, conduct, analysis and reporting of trials across a range of clinical areas including trauma, rehabilitation, and surgical trials. I also perform secondary analyses of trial data and contribute to methodological research projects.
My research interests include randomisation approaches, in particular investigating how best to select the optimal strategy.
Prior to joining OCTRU I obtained an MMath in Mathematics from Durham University and completed my PhD at King's College London. My PhD research concerned the use of Bayesian mixed models to combine both randomised controlled trial data and routine clinical practice data extracted from electronic medical records to provide less biased and more generalisable estimates of treatment effectiveness.
I joined OCTRU and CSM as a medical statistician in October 2017.
Key publications
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A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia.
Journal article
Knight R. et al, (2018), Dement geriatr cogn disord, 45, 131 - 151
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COmmunity-based Rehabilitation after Knee Arthroplasty (CORKA): statistical analysis plan for a randomised controlled trial.
Journal article
Vadher K. et al, (2018), Trials, 19
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Wound Healing In Surgery for Trauma (WHIST): statistical analysis plan for a randomised controlled trial comparing standard wound management with negative pressure wound therapy.
Journal article
Knight R. et al, (2019), Trials, 20
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Optimal randomisation strategies – simple, stratified or minimised: lessons from the WHIST trial
Poster
KNIGHT R. et al, (2019)
Recent publications
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Negative-pressure wound therapy compared with standard dressings following surgical treatment of major trauma to the lower limb: the WHiST RCT.
Journal article
Costa ML. et al, (2020), Health technol assess, 24, 1 - 86
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Current practice in analysing and reporting binary outcome data-a review of randomised controlled trial reports.
Journal article
Rombach I. et al, (2020), Bmc med, 18
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A multi-centre prospective randomised equivalence trial of a soft bandage and immediate discharge versus current treatment with rigid immobilisation for torus fractures of the distal radius in children: Protocol for the Forearm Fracture Recovery in Children Evaluation Trial (FORCE)
Journal article
ACHTEN J. et al, (2020), Bone and joint journal
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The forearm fracture recovery in children evaluation (FORCE): statistical and health economic analysis plan for an equivalence randomised controlled trial comparing soft bandage and immediate discharge versus current treatment with rigid immobilisation for torus fractures of the distal radius in children
Journal article
KNIGHT R. et al, (2020), Bone and joint journal
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Study of Peri-Articular Anaesthetic for Replacement of the Knee (SPAARK): study protocol for a patient-blinded, randomised controlled superiority trial of liposomal bupivacaine.
Journal article
Knight R. et al, (2019), Trials, 20