Ruth Knight
MMath, PhD
Senior Medical Statistician
I contribute statistical expertise to the design, conduct, analysis and reporting of trials across a range of clinical areas including trauma, rehabilitation, and surgical trials. I also perform secondary analyses of trial data and contribute to methodological research projects.
My research interests include randomisation approaches, in particular investigating how best to select the optimal strategy.
Prior to joining OCTRU I obtained an MMath in Mathematics from Durham University and completed my PhD at King's College London. My PhD research concerned the use of Bayesian mixed models to combine both randomised controlled trial data and routine clinical practice data extracted from electronic medical records to provide less biased and more generalisable estimates of treatment effectiveness.
I joined OCTRU and CSM as a medical statistician in October 2017.
Key publications
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A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia.
Journal article
Knight R. et al, (2018), Dement geriatr cogn disord, 45, 131 - 151
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Effect of Incisional Negative Pressure Wound Therapy vs Standard Wound Dressing on Deep Surgical Site Infection After Surgery for Lower Limb Fractures Associated With Major Trauma: The WHIST Randomized Clinical Trial.
Journal article
Costa ML. et al, (2020), Jama, 323, 519 - 526
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COmmunity-based Rehabilitation after Knee Arthroplasty (CORKA): statistical analysis plan for a randomised controlled trial.
Journal article
Vadher K. et al, (2018), Trials, 19
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Wound Healing In Surgery for Trauma (WHIST): statistical analysis plan for a randomised controlled trial comparing standard wound management with negative pressure wound therapy.
Journal article
Knight R. et al, (2019), Trials, 20
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Optimal randomisation strategies – simple, stratified or minimised: lessons from the WHIST trial
Poster
KNIGHT R. et al, (2019)
Recent publications
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Early patient-reported outcomes from primary hip and knee arthroplasty have improved over the past seven years : an analysis of the NHS PROMs dataset.
Journal article
Sabah SA. et al, (2022), Bone joint j, 104-B, 687 - 695
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Do torus fractures of the wrist in children require immobilisation? A randomised controlled equivalence trial
Journal article
PERRY D. et al, (2022), The lancet
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Economic outcomes associated with deep surgical site infection from lower limb fractures following major trauma.
Journal article
Png ME. et al, (2022), Bone jt open, 3, 398 - 403
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Anti-TNF (adalimumab) injection for the treatment of adults with frozen shoulder during the pain predominant stage protocol for a multi-centre, randomised, double blind, parallel group, feasibility trial
Journal article
Hopewell S. et al, (2022), Nihr open research, 2, 28 - 28
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Efficacy of Liposomal Bupivacaine and Bupivacaine Hydrochloride vs Bupivacaine Hydrochloride Alone as a Periarticular Anesthetic for Patients Undergoing Knee Replacement: A Randomized Clinical Trial.
Journal article
Hamilton TW. et al, (2022), Jama surg