Ruth Knight
MMath, PhD
Senior Medical Statistician
I contribute statistical expertise to the design, conduct, analysis and reporting of trials across a range of clinical areas including trauma, rehabilitation, and surgical trials. I also perform secondary analyses of trial data and contribute to methodological research projects.
My research interests include randomisation approaches, in particular investigating how best to select the optimal strategy.
Prior to joining OCTRU I obtained an MMath in Mathematics from Durham University and completed my PhD at King's College London. My PhD research concerned the use of Bayesian mixed models to combine both randomised controlled trial data and routine clinical practice data extracted from electronic medical records to provide less biased and more generalisable estimates of treatment effectiveness.
I joined OCTRU and CSM as a medical statistician in October 2017.
Key publications
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A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia.
Journal article
Knight R. et al, (2018), Dement geriatr cogn disord, 45, 131 - 151
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COmmunity-based Rehabilitation after Knee Arthroplasty (CORKA): statistical analysis plan for a randomised controlled trial.
Journal article
Vadher K. et al, (2018), Trials, 19
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Wound Healing In Surgery for Trauma (WHIST): statistical analysis plan for a randomised controlled trial comparing standard wound management with negative pressure wound therapy.
Journal article
Knight R. et al, (2019), Trials, 20
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Optimal randomisation strategies – simple, stratified or minimised: lessons from the WHIST trial
Poster
KNIGHT R. et al, (2019)
Recent publications
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Patient reported function and quality of life following revision total knee arthroplasty: Analysis of 10,727 patients from the NHS PROMs programme
Journal article
KNIGHT R. et al, (2021), The journal of arthroplasty
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Chronic pain with neuropathic characteristics after surgery for major trauma to the lower limb: prevalence, predictors and association with pain severity, disability and quality of life in the UK WHiST trial
Journal article
KEENE D. et al, (2021), The journal of bone and joint surgery
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Corrigenda.
Journal article
Trompeter AJ. et al, (2021), Bone joint j, 103-B
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Infographic: The Orthopaedic Trauma Society classification of open fractures.
Journal article
Trompeter A. et al, (2020), Bone joint j, 102-B, 1467 - 1468
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Outpatient physiotherapy versus home-based rehabilitation for patients at risk of poor outcomes after knee arthroplasty: CORKA RCT.
Journal article
Barker KL. et al, (2020), Health technol assess, 24, 1 - 116