Ruth Knight
MMath, PhD
Senior Medical Statistician
I contribute statistical expertise to the design, conduct, analysis and reporting of trials across a range of clinical areas including trauma, rehabilitation, and surgical trials. I also perform secondary analyses of trial data and contribute to methodological research projects.
My research interests include randomisation approaches, in particular investigating how best to select the optimal strategy.
Prior to joining OCTRU I obtained an MMath in Mathematics from Durham University and completed my PhD at King's College London. My PhD research concerned the use of Bayesian mixed models to combine both randomised controlled trial data and routine clinical practice data extracted from electronic medical records to provide less biased and more generalisable estimates of treatment effectiveness.
I joined OCTRU and CSM as a medical statistician in October 2017.
Key publications
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A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia.
Journal article
Knight R. et al, (2018), Dement geriatr cogn disord, 45, 131 - 151
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COmmunity-based Rehabilitation after Knee Arthroplasty (CORKA): statistical analysis plan for a randomised controlled trial.
Journal article
Vadher K. et al, (2018), Trials, 19
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Wound Healing In Surgery for Trauma (WHIST): statistical analysis plan for a randomised controlled trial comparing standard wound management with negative pressure wound therapy.
Journal article
Knight R. et al, (2019), Trials, 20
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Optimal randomisation strategies – simple, stratified or minimised: lessons from the WHIST trial
Poster
KNIGHT R. et al, (2019)
Recent publications
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Azithromycin versus standard care in patients with mild-to-moderate COVID-19 (ATOMIC2): an open-label, randomised trial.
Journal article
Hinks TSC. et al, (2021), Lancet respir med
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FORCE: A randomised controlled trial of offer of bandage versus rigid immobilisation in the treatment of torus fractures of the distal radius in children. Final Report in Production
Journal article
PERRY D. et al, (2021), Nihr journals library
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Letter to the editor regarding "Incomparability of treatment groups is often blindly ignored in randomised controlled trials - a post hoc analysis of baseline characteristic tables".
Journal article
Knight R. and Cook JA., (2021), J clin epidemiol
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Study of Peri-Articular Anaesthetic for Replacement of the Knee (SPAARK): statistical analysis plan for a randomised controlled trial assessing the effectiveness of peri-articular liposomal bupivacaine plus bupivacaine hydrochloride compared with bupivacaine hydrochloride alone
Journal article
Wang A. et al, (2021), Trials
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Study of Peri-Articular Anaesthetic for Replacement of the Knee (SPAARK): statistical analysis plan for a randomised controlled trial assessing the effectiveness of peri-articular liposomal bupivacaine plus bupivacaine hydrochloride compared with bupivacaine hydrochloride alone
Journal article
STOKES J. et al, (2021), Trials