Research Fellow in Trial Methodology (CONSORT & SPIRIT Reporting Guidelines)
My main areas of interest are clinical trial methodology and transparent, complete reporting of randomised controlled trials. I joined the Oxford Clinical Trials Research Unit (OCTRU) and Centre for Statistics in Medicine (CSM) in May 2022 as a Research Fellow in Trial Methodology. I am working on the MRC–NIHR-funded project to update the SPIRIT 2013 (Standard Protocol Items: Recommendations for Interventional Trials) and CONSORT 2010 (CONsolidated Standards Of Reporting Trials) Statements.
Before joining the OCTRU/CSM I spent seven years in Japan working in the researcher services industry, helping non-native English-speaking researchers and clinicians to publish their research. I reviewed and edited manuscripts; trained freelance medical writers, reviewers and editors; and provided training on ethical and transparent reporting and English academic writing.
I completed a BA in Physiology in 2008 and a DPhil in Molecular Biology in 2013 at the University of Oxford, and am currently in the final stages of a part-time MSc in Clinical Trials with the London School of Hygiene and Tropical Medicine.
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.
Arredouani A. et al, (2015), J biol chem, 290, 21376 - 21392
Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.
Lear PV. et al, (2015), Endocrinology, 156, 975 - 986
TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.
Ruas M. et al, (2014), Mol cell biol, 34, 3981 - 3992
Ca(2+) signals, NAADP and two-pore channels: role in cellular differentiation.
Parrington J. and Tunn R., (2014), Acta physiol (oxf), 211, 285 - 296