Contact information

Email	susan.dutton@csm.ox.ac.uk
Tel	+44 (0)1865 223451

My connections

Centre for Statistics in Medicine Research Group
Oxford Clinical Trials Research Unit Research Group
GRASP Research Group
MRC Pathfinder Award Research Group
MANTIS Research Group

Susan Dutton

BSc, MSc

OCTRU Lead Statistician

Senior Medical Statistician

Expert in statistics and clinical trial methodology

I am an experienced senior statistician working with medical professionals to design, achieve grant funding, conduct, analyse and report randomised clinical trials. I oversee an expanding group of medical statisticians at the Oxford Clinical Trials Research Unit – embedded in the Centre for Statistics in Medicine (CSM) – where I provide statistical management and input into all five therapeutic streams: musculoskeletal and rheumatology, rehabilitation and trauma, surgical interventions and oncology. I also teach short courses, workshops and hour-long training bites on how to conduct a trial, and run the annual week-long CSM Randomised Clinical Trials Course.

My expertise range from simple standard two-arm parallel group trials to complex multi-arm trials, factorial trials and trials within a cohort. I have worked on all aspects of intervention development, from early phase and pilot/feasibility studies to phase III pragmatic randomised trials, investigating drug and medical device interventions as well as complex rehabilitation and surgical interventions.

I provide independent statistical expertise to external bodies such as a NICE Technology Appraisal Committee, Data and Safety Monitoring Committees and Trial Steering Committees. I am the statistical editor of Maturitas and provide independent peer review for grant applications, final study reports and journal publications. I am a member of the UKCRC Statistics Group and the NIHR Statistics Group.

My career started in medical statistics in Liverpool at the Congenital Malformations Registry and then moved to Oxford to explore the geographical distribution of childhood cancers around nuclear installations. I joined CSM as an oncology trial statistician in 2007 and was appointed OCTRU Lead Statistician in 2013.

In my spare time, I am an obsessive patchwork and quilter, and enjoy reading, walking, geology, theatre trips and holidays to mountains and islands.

Clinical and cost-effectiveness of progressive exercise compared with best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: protocol for a 2x2 factorial randomised controlled trial (the GRASP trial).
Hopewell S. et al, (2017), BMJ open, 7
Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer.
Petty RD. et al, (2017), Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 35, 2279 - 2287
Data Monitoring Committee overseeing multiple international randomised controlled trials
Chiocchia V. et al, (2017), Trials
Meeting abstracts from the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials
(2017), Trials, 18
Characteristics and Dissemination of Phase 1 Trials Approved by a UK Regional Office in 2012.
Odutayo A. et al, (2017), JAMA, 317, 1799 - 1801
Association between trial registration and positive study findings: cross sectional study (Epidemiological Study of Randomized Trials-ESORT).
Odutayo A. et al, (2017), BMJ : British Medical Journal, 356
COmmunity-based Rehabilitation after Knee Arthroplasty (CORKA): study protocol for a randomised controlled trial.
Barker KL. et al, (2016), Trials, 17
Multivariate analysis of paired data: a review of methods for paired organ systems
Chiocchia V. et al, (2016)
Core Outcomes for Colorectal Cancer Surgery: A Consensus Study.
McNair AG. et al, (2016), PLoS medicine, 13
Trial outcomes and information for clinical decision-making: a comparative study of opinions of health professionals.
McNair AG. et al, (2016), Trials, 17
ARCII: A phase II trial of the HIV protease inhibitor Nelfinavir in combination with chemoradiation for locally advanced inoperable pancreatic cancer.
Wilson JM. et al, (2016), Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 119, 306 - 311
A Multi-institutional Analysis of Perioperative Outcomes in 106 Men Who Underwent Radical Prostatectomy for Distant Metastatic Prostate Cancer at Presentation.
Sooriakumaran P. et al, (2016), European urology, 69, 788 - 794
ARCII: A phase II trial of the HIV protease inhibitor Nelfinavir in combination with chemoradiation for locally advanced inoperable pancreatic cancer
Dutton S., (2016), Radiotherapy and Oncology
Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer.
Hill EJ. et al, (2016), Clinical cancer research : an official journal of the American Association for Cancer Research, 22, 1922 - 1931
Predictive Factors for Time to Progression after Hyperthermic Mitomycin C Treatment for High-Risk Non-Muscle Invasive Urothelial Carcinoma of the Bladder: An Observational Cohort Study of 97 Patients.
Sooriakumaran P. et al, (2016), Urologia internationalis, 96, 83 - 90
Synthesis and summary of patient-reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery.
McNair AG. et al, (2015), Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 17, O217 - O229
ARCII: Nelfinavir, a hypoxia-modifying agent, in combination with chemoradiotherapy (CRT) in locally-advanced pancreatic cancer (LAPC)-Mechanism and clinical outcomes.
Wilson JM. et al, (2015), JOURNAL OF CLINICAL ONCOLOGY, 33
Aberrant P53 expression lacks prognostic or predictive significance in colorectal cancer: results from the VICTOR trial.
McGregor MJ. et al, (2015), Anticancer research, 35, 1641 - 1645
Single arm NCRI phase II study of CHOP in combination with Ofatumumab in induction and maintenance for patients with newly diagnosed Richter's syndrome.
Eyre TA. et al, (2015), BMC cancer, 15
Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review protocol.
Vollam SA. et al, (2015), Systematic reviews, 4
Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma.
Dahle-Smith Å. et al, (2015), Molecular cytogenetics, 8
A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol.
Nicum S. et al, (2014), BMC cancer, 14
Protocol for the Femoroacetabular Impingement Trial (FAIT): a multi-centre randomised controlled trial comparing surgical and non-surgical management of femoroacetabular impingement.
Palmer AJ. et al, (2014), Bone & joint research, 3, 321 - 327
Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial.
Dutton SJ. et al, (2014), The Lancet. Oncology, 15, 894 - 904
Multicenter randomized controlled trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme: EnROL.
Kennedy RH. et al, (2014), Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32, 1804 - 1811
Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial.
Spathis A. et al, (2014), Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32, 1882 - 1888
Epidermal growth factor receptor copy number gain (EGFR CNG) and response to gefitinib in esophageal cancer (EC): Results of a biomarker analysis of a phase Ill trial of gefitinib versus placebo (TRANS-COG).
Petty RD. et al, (2014), JOURNAL OF CLINICAL ONCOLOGY, 32
The SPIRIT 2013 Statement.
Dutton SJ., (2014), Maturitas, 78, 1 - 2
External validation of multivariable prediction models: a systematic review of methodological conduct and reporting.
Collins GS. et al, (2014), BMC medical research methodology, 14
FOXFIRE protocol: an open-label, randomised, phase III trial of 5-fluorouracil, oxaliplatin and folinic acid (OxMdG) with or without interventional Selective Internal Radiation Therapy (SIRT) as first-line treatment for patients with unresectable liver-only or liver-dominant metastatic colorectal cancer.
Dutton SJ. et al, (2014), BMC cancer, 14
The DietCompLyf study: a prospective cohort study of breast cancer survival and phytoestrogen consumption.
Swann R. et al, (2013), Maturitas, 75, 232 - 240
Phase II clinical trial of six mercaptopurine (6MP) and methotrexate in patients with BRCA-defective tumors.
Nicum S. et al, (2013), JOURNAL OF CLINICAL ONCOLOGY, 31
A multicenter, randomized, double-blinded, placebo-controlled trial of modafinil for lung cancer-related fatigue: Dose response and patient satisfaction data.
Fife K. et al, (2013), JOURNAL OF CLINICAL ONCOLOGY, 31
The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial.
Huijbers A. et al, (2013), Annals of oncology : official journal of the European Society for Medical Oncology, 24, 179 - 185
Study protocol: A multi-centre, double blind, randomised, placebo-controlled, parallel group, phase II trial (RIDD) to determine the efficacy of intra-nodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with an embedded dose response study.
Nanchahal J. et al, (2013), Wellcome Open Research, 2, 37 - 37
A systematic review of outcome reporting in colorectal cancer surgery.
Whistance RN. et al, (2013), Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 15, e548 - e560
Referral proformas improve compliance to national colorectal 2-week wait targets: does this affect cancer detection rates?
Jani A. et al, (2012), Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 14, 1351 - 1356
Quantification of subclonal distributions of recurrent genomic aberrations in paired pre-treatment and relapse samples from patients with B-cell chronic lymphocytic leukemia.
Knight SJ. et al, (2012), Leukemia, 26, 1564 - 1575
EnROL: a multicentre randomised trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme.
Kennedy RH. et al, (2012), BMC cancer, 12
Target decision to delivery intervals for emergency caesarean section based on neonatal outcomes and three year follow-up.
Pearson GA. et al, (2011), European journal of obstetrics, gynecology, and reproductive biology, 159, 276 - 281
Evidence to support the single-dose over the two-dose protocol for routine antenatal anti-D Rhesus prophylaxis: a prospective observational study.
MacKenzie IZ. et al, (2011), European journal of obstetrics, gynecology, and reproductive biology, 158, 42 - 46
Bisphosphonates and oesophageal cancer risk: where are we now?
Rozenberg S. and Dutton S., (2011), Maturitas, 68, 106 - 108
Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes.
Boutron I. et al, (2010), JAMA, 303, 2058 - 2064
Reporting performance of prognostic models in cancer: a review.
Mallett S. et al, (2010), BMC medicine, 8
Reporting methods in studies developing prognostic models in cancer: a review.
Mallett S. et al, (2010), BMC medicine, 8
The quality of reports of randomised trials in 2000 and 2006: comparative study of articles indexed in PubMed.
Hopewell S. et al, (2010), BMJ : British Medical Journal, 340
FOXFIRE: a phase III clinical trial of chemo-radio-embolisation as first-line treatment of liver metastases in patients with colorectal cancer.
Sharma RA. et al, (2008), Clinical oncology (Royal College of Radiologists (Great Britain)), 20, 261 - 263
A multi-centre retrospective cohort study comparing the efficacy, safety and cost-effectiveness of hysterectomy and uterine artery embolisation for the treatment of symptomatic uterine fibroids. The HOPEFUL study.
Hirst A. et al, (2008), Health technology assessment (Winchester, England), 12, 1 - iii
Uterine artery embolisation or hysterectomy for the treatment of symptomatic uterine fibroids: a cost-utility analysis of the HOPEFUL study.
Wu O. et al, (2007), BJOG : an international journal of obstetrics and gynaecology, 114, 1352 - 1362
Management of shoulder dystocia: trends in incidence and maternal and neonatal morbidity.
MacKenzie IZ. et al, (2007), Obstetrics and gynecology, 110, 1059 - 1068
A UK multicentre retrospective cohort study comparing hysterectomy and uterine artery embolisation for the treatment of symptomatic uterine fibroids (HOPEFUL study): main results on medium-term safety and efficacy.
Dutton S. et al, (2007), BJOG : an international journal of obstetrics and gynaecology, 114, 1340 - 1351

Key Publications

Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial.
Dutton SJ. et al, (2014), The Lancet. Oncology, 15, 894 - 904
Multicenter randomized controlled trial of conventional versus laparoscopic surgery for colorectal cancer within an enhanced recovery programme: EnROL.
Kennedy RH. et al, (2014), Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32, 1804 - 1811
Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial.
Spathis A. et al, (2014), Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32, 1882 - 1888
Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes.
Boutron I. et al, (2010), JAMA, 303, 2058 - 2064
The quality of reports of randomised trials in 2000 and 2006: comparative study of articles indexed in PubMed.
Hopewell S. et al, (2010), BMJ : British Medical Journal, 340

Recent Publications

Clinical and cost-effectiveness of progressive exercise compared with best practice advice, with or without corticosteroid injection, for the treatment of rotator cuff disorders: protocol for a 2x2 factorial randomised controlled trial (the GRASP trial).
Hopewell S. et al, (2017), BMJ open, 7
Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer.
Petty RD. et al, (2017), Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 35, 2279 - 2287
Data Monitoring Committee overseeing multiple international randomised controlled trials
Chiocchia V. et al, (2017), Trials
Meeting abstracts from the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials
(2017), Trials, 18
Characteristics and Dissemination of Phase 1 Trials Approved by a UK Regional Office in 2012.
Odutayo A. et al, (2017), JAMA, 317, 1799 - 1801

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