Tim Maughan
MA MB BS FRCP FRCR MD (Cantab)
Professor of Clinical Oncology and Clinical Director of the Medical Research Centre (MRC)/Cancer Research UK Gray Institute for Radiation Oncology and Biology
- Theme leader - OCTRU oncology theme, Honorary Consultant Clinical Oncologist and Director of Research and Development for the Division of Surgery and Oncology at the Oxford Cancer Centre, Churchill Hospital
I lead the Clinical Research Programme at the Gray Institute, aiming to deliver a step change in the effectiveness of radiotherapy through the evaluation of novel scientific approaches derived from the Institute's scientists in hypothesis-driven clinical trials. In addition my research aims to identify means to select patients for appropriate therapy through the use of functional imaging and biomarkers.
My research interests focus on the treatment of patients with colorectal cancer and I am involved extensively at the UK level in clinical trial design and execution in gastrointestinal cancers. FOCUS4 is a molecularly stratified, multi-arm, multi-stage (MAMS) design, multi-site randomised trials programme for patients with colorectal cancer (CRC). During the initial registration period, all patients are treated with standard chemotherapy and considered for a standard treatment break if they have responding or stable disease after 16 weeks of chemotherapy. During the registration period, biomarker testing will be performed on their original tumour specimens to determine which specific drug(s) may be most appropriate to test during interruption of chemotherapy after 16 weeks. The patient will then be offered entry into a specific trial on the basis of their molecular cohort.
Key publications
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Journal article
Mukherjee S. et al, (2013), Lancet oncol, 14, 317 - 326
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Journal article
Adams RA. et al, (2011), Lancet oncol, 12, 642 - 653
Recent publications
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Validation of High-Performance Low-Field-Strength T1-weighted neuroimaging sequence modelling
Conference paper
WHYNTIE TOM. et al, (2021)
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Journal article
Malla SB. et al, (2021), Clin cancer res, 27, 288 - 300
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Journal article
Viratham Pulsawatdi A. et al, (2020), Mol oncol
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Journal article
Mann EH. and Maughan TS., (2020), Ann oncol
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Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning
Journal article
VERRILL C. et al, (2020), Gut