Research groups
Viveka Mayya
Postdoctoral Researcher
Quantitative analysis of immune synapse dynamics
I obtained my Ph.D. from the University of Connecticut (U.S.A.). Working in the laboratory of Dr. David K. Han, I developed and implemented proteomic methodologies for quantitative analysis of protein phosphorylation. This enabled us to exhaustively catalogue the changes in phosphorylation in the T cell proteome during TCR signalling. I joined Prof. Michael Dustin's lab at NYU Medical Center (U.S.A.) for post-doctoral work on immune synapse dynamics, which I am continuing here at the Kennedy Institute.
We have developed a MATLAB-based package called TIAM for the analysis of multi-dimensional images of T cells. We make use of the micro-contact printing technology to create artificial surfaces that emulate the main features of antigen presentation in lymphoid organs. Live cell imaging data of T cell behaviour on these artificial surfaces is analysed using TIAM to build quantitative models of immune synapse dynamics.
Recent publications
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What Scales the T Cell Response?
Journal article
Mayya V. and Dustin ML., (2016), Trends in immunology, 37, 513 - 522
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Integrative analysis of T cell motility from multi-channel microscopy data using TIAM.
Journal article
Mayya V. et al, (2015), Journal of immunological methods, 416, 84 - 93
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T cell antigen receptor activation and actin cytoskeleton remodeling.
Journal article
Kumari S. et al, (2014), Biochimica et biophysica acta, 1838, 546 - 556
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Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation.
Journal article
Best JA. et al, (2013), Nature immunology, 14, 404 - 412
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Phosphoproteomics by mass spectrometry: insights, implications, applications and limitations.
Journal article
Mayya V. and Han DK., (2009), Expert review of proteomics, 6, 605 - 618