Research groups
Viveka Mayya
Postdoctoral Researcher
Quantitative analysis of immune synapse dynamics
I obtained my Ph.D. from the University of Connecticut (U.S.A.). Working in the laboratory of Dr. David K. Han, I developed and implemented proteomic methodologies for quantitative analysis of protein phosphorylation. This enabled us to exhaustively catalogue the changes in phosphorylation in the T cell proteome during TCR signalling. I joined Prof. Michael Dustin's lab at NYU Medical Center (U.S.A.) for post-doctoral work on immune synapse dynamics, which I am continuing here at the Kennedy Institute.
We have developed a MATLAB-based package called TIAM for the analysis of multi-dimensional images of T cells. We make use of the micro-contact printing technology to create artificial surfaces that emulate the main features of antigen presentation in lymphoid organs. Live cell imaging data of T cell behaviour on these artificial surfaces is analysed using TIAM to build quantitative models of immune synapse dynamics.
Recent publications
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Multifaceted influence of pre-mitotic cytotoxicity of primed CD8 T cells on immunity and infection
Journal article
Dandamudi DB. et al, (2018)
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Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering
Journal article
Cai H. et al, (2018), Nature Nanotechnology, 13, 610 - 617
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Durable Interactions of T Cells with T Cell Receptor Stimuli in the Absence of a Stable Immunological Synapse
Journal article
Mayya V. et al, (2018), Cell Reports, 22, 340 - 349
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Comprehensive Analysis of Immunological Synapse Phenotypes Using Supported Lipid Bilayers.
Journal article
Valvo S. et al, (2017), Methods in molecular biology (Clifton, N.J.), 1584, 423 - 441
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What Scales the T Cell Response?
Journal article
Mayya V. and Dustin ML., (2016), Trends in immunology, 37, 513 - 522